Antibiotic resistance in Pseudomonas aeruginosa–Mechanisms, epidemiology and evolution

J Botelho, F Grosso, L Peixe - Drug resistance updates, 2019 - Elsevier
Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …

Targeting a highly conserved domain in bacterial histidine kinases to generate inhibitors with broad spectrum activity

CA Fihn, EE Carlson - Current opinion in microbiology, 2021 - Elsevier
Highlights•CA domain of bacterial HKs presents a novel anti-virulence or antibiotic
target.•CA domain targeted molecules can inhibit multiple HKs, increasing effectiveness.• …

Microbial hitchhiking: how Streptomyces spores are transported by motile soil bacteria

AR Muok, D Claessen, A Briegel - The ISME journal, 2021 - academic.oup.com
Streptomycetes are sessile bacteria that produce metabolites that impact the behavior of
microbial communities. Emerging studies have demonstrated that Streptomyces spores are …

Determination of the two-component systems regulatory network reveals core and accessory regulations across Pseudomonas aeruginosa lineages

J Trouillon, L Imbert, AM Villard, T Vernet… - Nucleic Acids …, 2021 - academic.oup.com
Pseudomonas aeruginosa possesses one of the most complex bacterial regulatory
networks, which largely contributes to its success as a pathogen. However, most of its …

Exposure to endocrine disruptors promotes biofilm formation and contributes to increased virulence of Pseudomonas aeruginosa

A Thiroux, J Labanowski, N Venisse… - Environmental …, 2023 - Wiley Online Library
Anthropogenic activities contribute to the spread of chemicals considered as endocrine
disruptors (ED) in freshwater ecosystems. While several studies have reported interactions …

[HTML][HTML] Antibiotic-resistant microbial populations in urban receiving waters and wastewaters from Tanzania

AS Ripanda, MJ Rwiza, EC Nyanza, H Miraji… - Environmental …, 2023 - Elsevier
Antimicrobial resistance against certain medications in the pathogenic microbial community
is globally increasing due to the continual discharge and disposal of pharmaceuticals in the …

Swarming of P. aeruginosa: through the lens of biophysics

JL Bru, SJ Kasallis, NM Høyland-Kroghsbo… - Biophysics …, 2023 - pubs.aip.org
Swarming is a collective flagella-dependent movement of bacteria across a surface that is
observed across many species of bacteria. Due to the prevalence and diversity of this …

Foraging signals promote swarming in starving Pseudomonas aeruginosa

D Badal, AV Jayarani, MA Kollaran, D Prakash, MP… - MBio, 2021 - Am Soc Microbiol
The opportunistic human pathogen Pseudomonas aeruginosa is known for exhibiting
diverse forms of collective behaviors, like swarming motility and biofilm formation. Swarming …

Molecular Mechanisms Underlying the Regulation of Biofilm Formation and Swimming Motility by FleS/FleR in Pseudomonas aeruginosa

T Zhou, J Huang, Z Liu, Z Xu, L Zhang - Frontiers in Microbiology, 2021 - frontiersin.org
Pseudomonas aeruginosa, a major cause of nosocomial infection, can survive under
diverse environmental conditions. Its great adaptive ability is dependent on its multiple …

The two-component system FleS/FleR represses H1-T6SS via cyclic di-GMP signaling in Pseudomonas aeruginosa

T Zhou, J Huang, Z Liu, Q Lin, Z Xu… - Applied and …, 2022 - Am Soc Microbiol
The type VI secretion system (T6SS) is an important translocation apparatus that is widely
employed by Gram-negative bacteria to deliver toxic effectors into eukaryotic and prokaryotic …