Inflammation and tumor progression: signaling pathways and targeted intervention

H Zhao, L Wu, G Yan, Y Chen, M Zhou… - Signal transduction and …, 2021 - nature.com
Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy

D Bruni, HK Angell, J Galon - Nature Reviews Cancer, 2020 - nature.com
Abstract The international American Joint Committee on Cancer/Union for International
Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the …

Pathogenesis of allergic diseases and implications for therapeutic interventions

J Wang, Y Zhou, H Zhang, L Hu, J Liu, L Wang… - Signal transduction and …, 2023 - nature.com
Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

Chronic spontaneous urticaria: focus on pathophysiology to unlock treatment advances

A Kaplan, M Lebwohl, AM Giménez‐Arnau, M Hide… - Allergy, 2023 - Wiley Online Library
Chronic spontaneous urticaria (CSU) is a debilitating skin disease characterized by
intensely itchy wheals, angioedema, or both. Symptoms recur spontaneously, on a near …

Anti‐KIT antibody, barzolvolimab, reduces skin mast cells and disease activity in chronic inducible urticaria

D Terhorst‐Molawi, T Hawro, E Grekowitz, L Kiefer… - Allergy, 2023 - Wiley Online Library
Abstract Background Chronic inducible urticaria (CIndU) is characterized by mast cell (MC)‐
mediated wheals in response to triggers: cold in cold urticaria (ColdU) and friction in …

The ingenious mast cell: Contemporary insights into mast cell behavior and function

JS Dahlin, M Maurer, DD Metcalfe, G Pejler… - Allergy, 2022 - Wiley Online Library
Mast cells are (in) famous for their role in allergic diseases, but the physiological and
pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are …

Chronic urticaria and the pathogenic role of mast cells

D Elieh-Ali-Komi, M Metz, P Kolkhir… - Allergology …, 2023 - jstage.jst.go.jp
abstract The signs and symptoms of chronic urticaria (CU) are caused by the activation and
degranulation of skin mast cells (MCs). Recent studies have added to our understanding of …

Butyrate inhibits human mast cell activation via epigenetic regulation of FcεRI‐mediated signaling

J Folkerts, F Redegeld, G Folkerts, B Blokhuis… - Allergy, 2020 - Wiley Online Library
Background Short‐chain fatty acids (SCFAs) are fermented dietary components that regulate
immune responses, promote colonic health, and suppress mast cell–mediated diseases …

Mast cell silencing: A novel therapeutic approach for urticaria and other mast cell‐mediated diseases

M Metz, P Kolkhir, S Altrichter, F Siebenhaar… - Allergy, 2024 - Wiley Online Library
Chronic urticaria (CU) is a mast cell (MC)‐dependent disease with limited therapeutic
options. Current management strategies are directed at inhibiting IgE‐mediated activation of …

Recent advances in our understanding of mast cell activation–or should it be mast cell mediator disorders?

TC Theoharides, I Tsilioni, H Ren - Expert review of clinical …, 2019 - Taylor & Francis
Introduction: An increasing number of patients present with multiple symptoms affecting
many organs including the brain due to multiple mediators released by mast cells. These …