Phytocannabinoids are bioactive natural products found in some flowering plants, liverworts,
and fungi that can be beneficial for the treatment of human ailments such as pain, anxiety …

Cannabis is well-known for its numerous therapeutic activities, as demonstrated in pre-
clinical and clinical studies primarily due to its bioactive compounds. The Cannabis industry …

Objectives The objectives of this study were to determine basic oral pharmacokinetics, and
assess safety and analgesic efficacy of a cannabidiol (CBD) based oil in dogs with …

The determination and characterization of a cannabinoid receptor from brain are reported. A
biologically active bicyclic cannabinoid analgetic CP-55,940 was tntium-Iabeled to high …

[3H] CP 55,940, a radiolabeled synthetic cannabinoid, which is 10-100 times more potent in
vivo than delta 9-tetrahydrocannabinol, was used to characterize and localize a specific …

Abstract Δ 9-Tetrahydrocannabinol (THC) is the main source of the pharmacological effects
caused by the consumption of cannabis, both the marijuana-like action and the medicinal …

A multitude of roles for the endogenous cannabinoid system has been proposed by recent
research efforts. A large number of endogenous cannabinoid neurotransmitters or …

Although the medicinal properties of Cannabis species have been known for centuries, the
interest on its main active secondary metabolites as therapeutic alternatives for several …

Two commonly used models of hepatic drug clearance are examined. The “well-stirred”
model (model I) views the liver as a well-stirred compartment with concentration of drug in …

In drug discovery and nonclinical development the volume of distribution at steady state (V
ss) of each novel drug candidate is commonly determined under in vivo conditions …