Recently, developmental systems are investigated with increasing technological power. Still,
open questions remain, especially concerning self-organization capacity and its control …

Cell-to-cell communication mediates a plethora of cellular decisions and behaviors that are
crucial for the correct and robust development of multicellular organisms. Many of these …

Optogenetic perturbations, live imaging, and time-resolved ChIP-seq assays in Drosophila
embryos were used to dissect the ERK-dependent control of the HMG-box repressor …

Animal embryos are patterned by a handful of highly conserved inductive signals. Yet, in
most cases, it is unknown which pattern features (ie, spatial gradients or temporal dynamics) …

Optogenetic approaches are transforming quantitative studies of cell-signaling systems. A
recently developed photoswitchable mitogen-activated protein kinase kinase 1 (MEK1) …

Gamete development is a fundamental process that is highly conserved from early
eukaryotes to mammals. As germ cells develop, they must coordinate a dynamic series of …

In insect embryos, anteroposterior patterning is coordinated by the sequential expression of
the 'timer'genes caudal, Dichaete, and odd-paired, whose expression dynamics correlate …

Extracellular-signal-regulated kinase (ERK) signaling controls development and
homeostasis and is genetically deregulated in human diseases, including neurocognitive …

Organogenesis requires exquisite spatiotemporal coordination of cell morphogenesis,
migration, proliferation, and differentiation of multiple cell types. For gonads, this involves …

Terminal regions of Drosophila embryos are patterned by signaling through ERK, which is
genetically deregulated in multiple human diseases. Quantitative studies of terminal …