Thermostability, tunability, and tenacity of RNA as rubbery anionic polymeric materials in nanotechnology and nanomedicine—specific cancer targeting with …
RNA nanotechnology is the bottom-up self-assembly of nanometer-scale architectures,
resembling LEGOs, composed mainly of RNA. The ideal building material should be (1) …
resembling LEGOs, composed mainly of RNA. The ideal building material should be (1) …
Theory and modeling of RNA structure and interactions with metal ions and small molecules
In addition to continuous rapid progress in RNA structure determination, probing, and
biophysical studies, the past decade has seen remarkable advances in the development of …
biophysical studies, the past decade has seen remarkable advances in the development of …
Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography
Riboswitches are structural RNA elements that are generally located in the 5′ untranslated
region of messenger RNA. During regulation of gene expression, ligand binding to the …
region of messenger RNA. During regulation of gene expression, ligand binding to the …
Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP
SW Olson, AMW Turner, JW Arney, I Saleem… - Molecular cell, 2022 - cell.com
Summary 7SK is a conserved noncoding RNA that regulates transcription by sequestering
the transcription factor P-TEFb. 7SK function entails complex changes in RNA structure, but …
the transcription factor P-TEFb. 7SK function entails complex changes in RNA structure, but …
Optimized magnesium force field parameters for biomolecular simulations with accurate solvation, ion-binding, and water-exchange properties
Magnesium ions play an essential role in many vital processes. To correctly describe their
interactions in molecular dynamics simulations, an accurate parametrization is crucial …
interactions in molecular dynamics simulations, an accurate parametrization is crucial …
Synthesis and applications of RNAs with position-selective labelling and mosaic composition
Y Liu, E Holmstrom, J Zhang, P Yu, J Wang, MA Dyba… - Nature, 2015 - nature.com
Abstract Knowledge of the structure and dynamics of RNA molecules is critical to
understanding their many biological functions. Furthermore, synthetic RNAs have …
understanding their many biological functions. Furthermore, synthetic RNAs have …
Mg2+ ions: do they bind to nucleobase nitrogens?
Given the many roles proposed for Mg2+ in nucleic acids, it is essential to accurately
determine their binding modes. Here, we surveyed the PDB to classify Mg2+ inner-sphere …
determine their binding modes. Here, we surveyed the PDB to classify Mg2+ inner-sphere …
19F NMR‐Based Fragment Screening for 14 Different Biologically Active RNAs and 10 DNA and Protein Counter‐Screens
O Binas, V de Jesus, T Landgraf, AE Völklein… - …, 2021 - Wiley Online Library
We report here the nuclear magnetic resonance 19F screening of 14 RNA targets with
different secondary and tertiary structure to systematically assess the druggability of RNAs …
different secondary and tertiary structure to systematically assess the druggability of RNAs …
Advanced approaches for elucidating structures of large RNAs using NMR spectroscopy and complementary methods
A Kotar, HN Foley, KM Baughman, SC Keane - Methods, 2020 - Elsevier
NMR spectroscopy is a key technique that has significantly advanced our understanding of
RNA structure and dynamics. However, determination of large RNA structures by NMR …
RNA structure and dynamics. However, determination of large RNA structures by NMR …
[HTML][HTML] Riboswitch mechanisms for regulation of P1 helix stability
JR Stagno, YX Wang - International Journal of Molecular Sciences, 2024 - mdpi.com
Riboswitches are highly structured RNA regulators of gene expression. Although found in all
three domains of life, they are particularly abundant and widespread in bacteria, including …
three domains of life, they are particularly abundant and widespread in bacteria, including …