Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
The BLAST programs are widely used tools for searching protein and DNA databases for
sequence similarities. For protein comparisons, a variety of definitional, algorithmic and …
sequence similarities. For protein comparisons, a variety of definitional, algorithmic and …
The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification1
The eukaryotic protein kinases make up a large superfamily of homologous proteins. They
are related by virtue of their kinase domains (also known as catalytic domains), which …
are related by virtue of their kinase domains (also known as catalytic domains), which …
Initial sequencing and analysis of the human genome
US DOE Joint Genome Institute: Hawkins Trevor 4 … - Nature, 2001 - nature.com
The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …
physiology, medicine and evolution. Here we report the results of an international …
Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human
Widmann, Christian, Spencer Gibson, Matthew B. Jarpe, and Gary L. Johnson. Mitogen-
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …
[HTML][HTML] Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling
T Hunter - Cell, 1995 - Elsevier
Protein phosphorylation plays a cardinal role in regulating many cellular processes in
eukaryotes. In particular, protein phosphorylation is a major currency of signal transduction …
eukaryotes. In particular, protein phosphorylation is a major currency of signal transduction …
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
ENDOGENOUS neuromodulatory molecules are commonly coupled to specific metabolic
enzymes to ensure rapid signal inactivation. Thus, acetylcholine is hydrolysed by …
enzymes to ensure rapid signal inactivation. Thus, acetylcholine is hydrolysed by …
[HTML][HTML] Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family
S Keeney, CN Giroux, N Kleckner - Cell, 1997 - cell.com
Meiotic recombination in S. cerevisiae is initiated by double-strand breaks (DSBs). In certain
mutants, breaks accumulate with a covalently attached protein, suggesting that cleavage is …
mutants, breaks accumulate with a covalently attached protein, suggesting that cleavage is …
[HTML][HTML] Biochemistry and genetics of von Willebrand factor
JE Sadler - Annual review of biochemistry, 1998 - annualreviews.org
Von Willebrand factor (VWF) is a blood glycoprotein that is required for normal hemostasis,
and deficiency of VWF, or von Willebrand disease (VWD), is the most common inherited …
and deficiency of VWF, or von Willebrand disease (VWD), is the most common inherited …
The Minimal Gene Complement of Mycoplasma genitalium
The complete nucleotide sequence (580,070 base pairs) of the Mycoplasma genitalium
genome, the smallest known genome of any free-living organism, has been determined by …
genome, the smallest known genome of any free-living organism, has been determined by …
Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism
MS Wold - Annual review of biochemistry, 1997 - annualreviews.org
Replication protein A [RPA; also known as replication factor A (RFA) and human single-
stranded DNA-binding protein] is a single-stranded DNA-binding protein that is required for …
stranded DNA-binding protein] is a single-stranded DNA-binding protein that is required for …