Infectious diseases remain an important global health problem. The interaction of a wide
range of pathogen bacteria with host cells from many different tissues is frequently mediated …

Glycosylation is one of the most important modifications of proteins and lipids, and cell
surface glycoconjugates are thought to play important roles in a variety of biological …

Repeated cycles of infections, caused mainly by Pseudomonas aeruginosa, combined with
a robust host immune response and tissue injury, determine the course and outcome of …

Lung antimicrobial proteins and peptides (AMPs) are major sentinels of innate immunity by
preventing microbial colonization and infection. Nevertheless bactericidal activity of AMPs …

Damage to endothelial glycocalyx impairs vascular barrier function and may contribute to
progression of chronic vascular disease. An early indicator is microalbuminuria resulting …

Neutrophil elastase (NE) is a major protease in the airways of patients with cystic fibrosis
(CF) that activates airway inflammation by several mechanisms. NE stimulates epithelial toll …

We have, in previous work developed, characterized and evaluated the biocompatibility of
an engineered hyaluronic acid nanogel. Here we assess the targetability of a hyaluronic …

Chronic infection is a hallmark of cystic fibrosis (CF) and the main contributor to morbidity.
Microbial infection in CF is complex, due to the number of different species that colonise the …

Immunostaining in lungs of patients who died with COVID-19 infection showed increased
intensity and distribution of chondroitin sulfate and decline in N-acetylgalactostamine-4 …

In the lung, glycosaminoglycans (GAGs) are dispersed in the extracellular matrix (ECM)
occupying the interstitial space between the capillary endothelium and the alveolar …