It has been known for over 100 years that acidosis decreases the contractility of cardiac
muscle. However, the mechanisms underlying this decrease are complicated because …

There is good evidence that elevated [Ca2+] i, produced by an influx of Ca2+ in exchange
for Na+, is the underlying pathology in reperfusion or reoxygenation damage. Further …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

The advent of balanced solutions for iv fluid resuscitation and replacement is imminent and
will affect any specialty involved in fluid management. Part of the background to their …

Hypoventilation, associated with hypercapnic acidosis (HCA), may improve outcome in
acute lung injury (ALI). We have recently reported that HCA per se protects against ALI. The …

Using highly purified sarcolemmal vesicles isolated from dog ventricles, we examined the
effects of pH on Na+-Ca2+ exchange. The initial rate of Nai+-dependent Ca2+ uptake is a …

The extracellular pH (pHo) and intracellular pH (pHi) were simultaneously measured with H
(+)-sensitive microelectrodes in the rabbit papillary muscle during normal arterial perfusion …

We compared the response of ventricular muscle from adult and neonatal rats to
hypercapnic acidosis. In adult muscle, acidosis caused an initial rapid fall of developed …

The calcium‐sensitive photoprotein aequorin was micro‐injected into cells of rat, ferret,
rabbit and cat papillary muscles. Aequorin light emission is a function of free intracellular …

Cellular calcium overload figures prominently in the pathogenesis of the contractile
dysfunction observed after brief periods of ischemia (myocardial stunning). Because …