The nucleus, a genome-containing organelle eponymous of eukaryotes, is enclosed by a
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …

Abstract The R2TP/Prefoldin-like (R2TP/PFDL) complex has emerged as a cochaperone
complex involved in the assembly of a number of critical protein complexes including …

Eukaryotic RNA polymerases (RNA pols) transcriptional processes have been extensively
investigated, and the structural analysis of eukaryotic RNA pols has been explored …

Coat protein complex I (COPI) vesicles mediate the retrograde transfer of cargo between
Golgi cisternae and from the Golgi to the endoplasmic reticulum (ER). However, their roles in …

Yeast Bud27, an unconventional prefoldin is reported to affect the expression of nutrient-
responsive genes, translation initiation and assembly of the multi-subunit eukaryotic RNA …

ABSTRACT RNA polymerase II (RNAPII) is one of the central enzymes in cell growth and
organizational development. It is a large macromolecular complex consisting of 12 subunits …

Little is known about the RNA polymerase III (Pol III) complex assembly and its transport to
the nucleus. We demonstrate that a missense cold-sensitive mutation, rpc128-1007, in the …

Rtr1 is an RNA polymerase II (RNA pol II) CTD-phosphatase that influences gene
expression during the transition from transcription initiation to elongation and during …

Recent studies suggest that RNA polymerase II (Pol II) has to be fully assembled before
being imported into the nucleus, while other reports indicate a distinct mechanism to import …

De novo methotrexate (MTX)‐resistance, whose underlying mechanism remains largely
unknown, usually leads to very poor prognosis in patients with osteosarcoma (OS). In this …