The spread of chronic wasting disease (CWD) during the last six decades has resulted in
cervid populations of North America where CWD has become enzootic. This insidious …

Intrinsically disordered proteins (IDPs) do not have rigid 3D structures, showing changes in
their folding depending on the environment or ligands. Intrinsically disordered proteins are …

Prion diseases are fatal neurodegenerative disorders in man and animal associated with
conformational conversion of a cellular prion protein (PrPc) into the pathologic isoform …

The NMR structures of the recombinant cellular form of the prion proteins (PrPC) of the cat
(Felis catus), dog (Canis familiaris), and pig (Sus scrofa), and of two polymorphic forms of …

Age at disease onset and rate of progression of transmissible spongiform encephalopathies
in man, sheep and mice are modulated by the host genome, in particular by the PrP gene …

Backgound: A conformational change seems to represent the major difference between the
scrapie prion protein (PrP Sc) and its normal cellular isoform (PrP C). We recently proposed …

Interspecies transmission of the transmissible spongiform encephalopathies (TSEs), or prion
diseases, can result in the adaptation and selection of TSE strains with an expanded host …

Publisher Summary The prevalence of identical global architectures for the proteins implies
that conformational transitions between the ubiquitous cellular form and the transmissible …

A total of 51 goats, including seven clinical cases, from the first herd in Greece reported to
have scrapie was examined to discern an association between scrapie susceptibility and …

Transmissible spongiform encephalopathies (TSEs) are neurological diseases that are
associated with the conversion of the normal host-encoded prion protein (PrP-sen) to an …