The raison d'être of meiosis is shuffling of genetic information via Mendelian segregation
and, within individual chromosomes, by DNA crossing-over. These outcomes are enabled …

The specialized two-stage meiotic cell division program halves a cell's chromosome
complement in preparation for sexual reproduction. This reduction in ploidy requires that in …

Meiotic crossovers are limited in number and are prevented from occurring close to each
other by crossover interference. In many species, crossover number is subject to sexual …

The formation of crossovers between homologous chromosomes is key to sexual
reproduction. In most species, crossovers are spaced further apart than would be expected if …

In sexually reproducing organisms, germ cells faithfully transmit the genome to the next
generation by forming haploid gametes, such as eggs and sperm. Although most meiotic …

Meiotic recombination is highly regulated to ensure precise segregation of homologous
chromosomes. Evidence from diverse organisms indicates that the synaptonemal complex …

Meiotic chromosomes efficiently transduce information along their length to regulate the
distribution of genetic exchanges (crossovers). However, the mode of signal transduction …

Sexual reproduction shuffles the parental genomes to generate new genetic combinations.
To achieve that, the genome is subjected to numerous double-strand breaks, the repair of …

Successful chromosome segregation into gametes depends on tightly regulated interactions
between the parental chromosomes. During meiosis, chromosomes are aligned end-to-end …

The synaptonemal complex (SC) is a zipper-like protein assembly that links homologous
chromosomes to regulate recombination and segregation during meiosis. The SC has been …