Progress and challenges in targeting the SARS-CoV-2 papain-like protease
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. The approval of vaccines
and small-molecule antivirals is vital in combating the pandemic. The viral polymerase …
and small-molecule antivirals is vital in combating the pandemic. The viral polymerase …
Targeting SARS-CoV-2 proteases for COVID-19 antiviral development
The emergence of severe acute respiratory syndrome (SARS-CoV-2) in 2019 marked the
third occurrence of a highly pathogenic coronavirus in the human population since 2003. As …
third occurrence of a highly pathogenic coronavirus in the human population since 2003. As …
The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery
SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2
papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus …
papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus …
[HTML][HTML] Crystal structure of SARS-CoV-2 papain-like protease
X Gao, B Qin, P Chen, K Zhu, P Hou, JA Wojdyla… - … Pharmaceutica Sinica B, 2021 - Elsevier
The pandemic of coronavirus disease 2019 (COVID-19) is changing the world like never
before. This crisis is unlikely contained in the absence of effective therapeutics or vaccine …
before. This crisis is unlikely contained in the absence of effective therapeutics or vaccine …
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection
JT Jan, TJR Cheng, YP Juang, HH Ma… - Proceedings of the …, 2021 - National Acad Sciences
The outbreak of COVID-19 caused by SARS-CoV-2 has resulted in more than 50 million
confirmed cases and over 1 million deaths worldwide as of November 2020. Currently, there …
confirmed cases and over 1 million deaths worldwide as of November 2020. Currently, there …
Identification of inhibitors of SARS-CoV-2 3CL-pro enzymatic activity using a small molecule in vitro repurposing screen
M Kuzikov, E Costanzi, J Reinshagen… - ACS pharmacology & …, 2021 - ACS Publications
Compound repurposing is an important strategy for the identification of effective treatment
options against SARS-CoV-2 infection and COVID-19 disease. In this regard, SARS-CoV-2 …
options against SARS-CoV-2 infection and COVID-19 disease. In this regard, SARS-CoV-2 …
Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19
E Kawakami, N Saiki, Y Yoneyama, C Moriya… - Cell Stem Cell, 2023 - cell.com
COVID-19 is linked to endotheliopathy and coagulopathy, which can result in multi-organ
failure. The mechanisms causing endothelial damage due to severe acute respiratory …
failure. The mechanisms causing endothelial damage due to severe acute respiratory …
Inhibitors of sars-cov-2 plpro
The emergence of SARS-CoV-2 causing the COVID-19 pandemic, has highlighted how a
combination of urgency, collaboration and building on existing research can enable rapid …
combination of urgency, collaboration and building on existing research can enable rapid …
Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies
LA Armstrong, SM Lange, V Dee Cesare, SP Matthews… - PloS one, 2021 - journals.plos.org
Of the 16 non-structural proteins (Nsps) encoded by SARS CoV-2, Nsp3 is the largest and
plays important roles in the viral life cycle. Being a large, multidomain, transmembrane …
plays important roles in the viral life cycle. Being a large, multidomain, transmembrane …
In vitro and in vivo models for studying SARS-CoV-2, the etiological agent responsible for COVID-19 pandemic
RB Rosa, WM Dantas, JCF do Nascimento… - Viruses, 2021 - mdpi.com
The emergence and rapid worldwide spread of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has prompted the scientific community to rapidly develop in …
coronavirus 2 (SARS-CoV-2) has prompted the scientific community to rapidly develop in …