Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

Wound healing is one of the most complex processes in the human body. It involves the
spatial and temporal synchronization of a variety of cell types with distinct roles in the …

The widespread availability of programmable site-specific nucleases now enables targeted
gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate …

Sprouting angiogenesis is a dynamic process in which endothelial cells collectively migrate,
shape new lumenized tubes, make new connections, and remodel the nascent network into …

The vertebrate body contains an extensive blood vessel network that forms, with a few
exceptions, by endothelial sprouting from the existing vasculature. This process, termed …

Angiogenesis, the growth of new blood vessels from pre-existing vasculature, is a key
process in several pathological conditions, including tumour growth and age-related …

Rationale: Familial recurrence studies provide strong evidence for a genetic component to
the predisposition to sporadic, nonsyndromic Tetralogy of Fallot (TOF), the most common …

Vascular remodeling under conditions of growth or exercise, or during recovery from arterial
restriction or blockage is essential for health, but mechanisms are poorly understood. It has …

Direct genomic manipulation at a specific locus is still not feasible in most vertebrate model
organisms. In vertebrate cell lines, genomic lesions at a specific site have been introduced …

Recent evidence indicates that growing blood-vessel sprouts consist of endothelial cells
with distinct cell fates and behaviours,; however, it is not clear what signals determine these …