Neurodevelopmental disorders (NDDs) are a class of disorders affecting brain development
and function and are characterized by wide genetic and clinical variability. In this review, we …

Abstract Between 1% and 3% of persons in general population are estimated to have some
degree of intellectual disability. A diagnosis of intellectual disability is based on clinical …

Intellectual disability (ID) can be caused by non-genetic and genetic factors, the latter being
responsible for more than 1700 ID-related disorders. The broad ID phenotypic and genetic …

INTRODUCTION The cerebral cortex, or neocortex, is critical to key mammalian skills such
as language, sociability, and sensorimotor control. This structure consists of dozens of …

We performed whole-genome sequencing (WGS) in 327 children with cerebral palsy (CP)
and their biological parents. We classified 37 of 327 (11.3%) children as having …

Intellectual disability (ID) has a prevalence of~ 2–3% in the general population, having a
large societal impact. The underlying cause of ID is largely of genetic origin; however …

Neurodevelopmental disorders (NDDs) encompass a group of complex conditions with
onset during the early developmental period. Such disorders are frequently associated with …

Mutations in the X-linked gene MECP2 cause Rett syndrome, a progressive neurological
disorder in which children develop normally for the first one or two years of life before …

Intellectual disability (ID) and autism spectrum disorder (ASD) are clinically and genetically
heterogeneous diseases. Recent whole exome sequencing studies indicated that genes …

Methods and Results: We identified monogenic ID/ASD conditions through PubMed and
other NCBI databases. Many such genes are located on the X chromosome (> 150 out of …