The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …

Increasing antimalarial drug resistance once again threatens effective antimalarial drug
treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are …

Infectious diseases are caused by microorganisms belonging to the class of bacteria,
viruses, fungi, or parasites. These pathogens are transmitted, directly or indirectly, and can …

Background Artemisinin resistance in Plasmodium falciparum has emerged in Southeast
Asia and now poses a threat to the control and elimination of malaria. Mapping the …

Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and
eliminate malaria. Polymorphisms in the kelch domain–carrying protein K13 are associated …

Background Emergence of artemisinin resistance in southeast Asia poses a serious threat to
the global control of Plasmodium falciparum malaria. Discovery of the K13 marker has …

The emergence of artemisinin resistance in Southeast Asia imperils efforts to reduce the
global malaria burden. We genetically modified the Plasmodium falciparum K13 locus using …

Summary Background Artemisinin resistance in Plasmodium falciparum lengthens parasite
clearance half-life during artemisinin monotherapy or artemisinin-based combination …

Background Artemisinin-resistant falciparum malaria has arisen in western Cambodia. A
concerted international effort is underway to contain artemisinin-resistant Plasmodium …

Microbial drug persistence is a widespread phenomenon in which a subpopulation of
microorganisms is able to survive antimicrobial treatment without acquiring resistance …