Although the entire coronary tree is exposed to the atherogenic effect of the systemic risk
factors, atherosclerotic lesions form at specific arterial regions, where low and oscillatory …

Atherosclerosis is the main cause of morbidity and mortality in the Western world.
Inflammation and blood flow alterations are new markers emerging as possible …

In arterial blood flow, the wall shear stress expresses the force per unit area exerted by the
wall on the fluid in a direction on the local tangent plane. There is substantial evidence that …

This review summarizes the current literature and the open questions regarding the
physiology and pathophysiology of the mechanical effects of heart rate on the vessel wall …

Several epidemiological studies have reported that an elevated heart rate is associated with
coronary atherosclerosis independently of other risk factors. In this review we explore the …

Background—The natural history of heterogeneous atherosclerotic plaques and the role of
local hemodynamic factors throughout their development are unknown. We performed a …

Endothelial dysfunction has been implicated as a key factor in the development of a wide
range of cardiovascular diseases, but its definition and mechanisms vary greatly between …

Background Computational modeling of cardiovascular flow is a growing and useful field,
but such simulations usually require the researcher to guess the flow's inlet and outlet …

The capabilities and limitations of various molecular viscosity models, in the left coronary
arterial tree, were analyzed via: molecular viscosity, local and global non-Newtonian …

INTRODUCTION: Blood flow induced shear stress plays an important role in platelet and
endothelial cell functions. The goal of this study was to investigate the effect of …