Cellular DNA is continuously transcribed into RNA by multisubunit RNA polymerases
(RNAPs). The continuity of transcription can be disrupted by DNA lesions that arise from the …

Global genome nucleotide excision repair (GG-NER) is the main pathway for the removal of
bulky lesions from DNA and is characterized by an extraordinarily wide substrate specificity …

Exposure to environmental mutagens increases the risk of cancer and genetic disorders. We
used Duplex Sequencing (DS), a high-accuracy error-corrected sequencing technology, to …

Mutagenicity testing is an essential component of health safety assessment. Duplex
Sequencing (DS), an emerging high-accuracy DNA sequencing technology, may provide …

The eukaryotic global genomic nucleotide excision repair (GG-NER) pathway is the major
mechanism that removes most bulky and some nonbulky lesions from cellular DNA. There is …

Apurinic/apyrimidinic (AP) sites are a class of highly mutagenic and toxic DNA lesions
arising in the genome from a number of exogenous and endogenous sources. Repair of AP …

RN ase J1 is the major 5′‐to‐3′ bacterial exoribonuclease. We demonstrate that in its
absence, RNA polymerases (RNAP s) are redistributed on DNA, with increased RNAP …

Patients with the genetic disease xeroderma pigmentosum (XP) who lack the capacity to
carry out nucleotides excision repair (NER) have a dramatically elevated risk of skin cancer …

Ultraviolet B (UVB) radiation represents a major carcinogen for the development of all skin
cancer types. Mechanistically, UVB induces damage to DNA in the form of lesions, including …

Altered protein function due to mutagenesis plays an important role in disease development.
This is perhaps most evident in tumorigenesis and the associated loss or gain of function of …