Adiponectin regulation and function

H Fang, RL Judd - Comprehensive Physiology, 2011 - Wiley Online Library
Adipose tissue is now recognized as an important endocrine organ, capable of secreting a
large number of endocrine factors which regulate a wide variety of physiological functions …

Leptin-aldosterone-neprilysin axis: identification of its distinctive role in the pathogenesis of the three phenotypes of heart failure in people with obesity

M Packer - Circulation, 2018 - Am Heart Assoc
Obesity (especially visceral adiposity) can be associated with 3 different phenotypes of heart
failure: heart failure with a reduced ejection fraction, heart failure with a preserved ejection …

Adiponectin and cardiovascular health: an update

X Hui, KSL Lam, PM Vanhoutte… - British journal of …, 2012 - Wiley Online Library
The global epidemic of obesity is accompanied by an increased prevalence of
cardiovascular disease (CVD), in particular stroke and heart attack. Dysfunctional adipose …

Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease

A Xu, PM Vanhoutte - American Journal of Physiology …, 2012 - journals.physiology.org
The heart and blood vessels are surrounded by epicardial and perivascular adipose tissues,
respectively, which play important roles in maintaining cardiovascular homeostasis by …

High-altitude ancestry and hypoxia acclimation have distinct effects on exercise capacity and muscle phenotype in deer mice

MA Lui, S Mahalingam, P Patel… - American Journal …, 2015 - journals.physiology.org
The hypoxic and cold environment at high altitudes requires that small mammals sustain
high rates of O2 transport for exercise and thermogenesis while facing a diminished O2 …

The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice

F Qin, DA Siwik, I Luptak, X Hou, L Wang, A Higuchi… - Circulation, 2012 - Am Heart Assoc
Background—Diet-induced obesity is associated with metabolic heart disease characterized
by left ventricular hypertrophy and diastolic dysfunction. Polyphenols such as resveratrol …

The role of adiponectin in human vascular physiology

AG Vaiopoulos, K Marinou, C Christodoulides… - International journal of …, 2012 - Elsevier
Adiponectin (ApN) is an adipose tissue-derived hormone which is involved in a wide variety
of physiological processes including energy metabolism, inflammation, and vascular …

Adiponectin and PPARγ: cooperative and interdependent actions of two key regulators of metabolism

O Astapova, T Leff - Vitamins & Hormones, 2012 - Elsevier
The recent advances in the understanding of adiponectin and other adipokines have
highlighted the role of adipose tissue as an active endocrine organ. One of the central …

Adiponectin and its isoforms in pathophysiology

M van Andel, AC Heijboer, ML Drent - Advances in clinical chemistry, 2018 - Elsevier
Adiponectin circulates in blood in multiple isoforms. High molecular weight (HMW)
adiponectin is thought to be most biologically active and promotes glucose uptake, insulin …

The sick adipose tissue: new insights into defective signaling and crosstalk with the myocardium

V Bermúdez, P Durán, E Rojas, MP Díaz… - Frontiers in …, 2021 - frontiersin.org
Adipose tissue (AT) biology is linked to cardiovascular health since obesity is associated
with cardiovascular disease (CVD) and positively correlated with excessive visceral fat …