Systemic osmoregulation is a vital process whereby changes in plasma osmolality, detected
by osmoreceptors, modulate ingestive behaviour, sympathetic outflow and renal function to …

Perturbations of cellular and systemic osmolarity severely challenge the function of all
organisms and are consequently regulated very tightly. Here we outline current evidence on …

Hypothalamic magnocellular neuroendocrine cells have unique electrical properties and a
remarkable capacity for morphological and synaptic plasticity. Their large somatic size, their …

Key points A growing body of evidence suggests that epithelial Na+ channels (ENaCs) in
the brain play a significant role in the regulation of blood pressure; however, the brain …

To understand the contribution of intrinsic membrane properties to the different in vivo firing
patterns of oxytocin (OT) and vasopressin (VP) neurones, in vitro studies are needed, where …

Osmoregulation is an essential homeostatic process that requires constant release of
vasopressin during sustained increases in plasma osmolality. The magnocellular …

Most neurons sense and code change, and when presented with a constant stimulus they
adapt, so as to be able to detect a fresh change. However, for some things it is important to …

Oxytocin secretion is required for successful reproduction. Oxytocin is synthesised by
magnocellular neurones of the hypothalamic supraoptic and paraventricular nuclei and the …

Moderate dehydration impairs concentration and co‐ordination, whereas severe
dehydration can cause seizures, brain damage or death. To slow the progression of …

The magnocellular neurosecretory cells (MNCs) of the hypothalamus regulate body fluid
balance by releasing the hormones vasopressin (VP) and oxytocin (OT) in an osmolality …