Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …

One of the most unexpected discoveries in molecular oncology, in the last decades, was the
identification of a new layer of protein coding gene regulation by transcripts that do not …

Objectives Chronic-plus-binge ethanol feeding activates neutrophils and exacerbates liver
injury in mice. This study investigates how recent excessive drinking affects peripheral …

Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide.
Although it has been known that hepatic stellate cells (HSCs) play critical roles in the …

The Notch pathway represents a highly conserved signaling network with essential roles in
regulation of key cellular processes and functions, many of which are critical for …

In recent decades, there have been tremendous improvements in burn care that have
allowed patients to survive severe burn injuries that were once fatal. However, a major …

Liver fibrosis is a wound‐healing response represented by excessive extracellular matrix
deposition. Activation of hepatic stellate cell (HSC) is the critical cellular basis for hepatic …

Purpose: The incidence of hepatocellular carcinoma is increasing in the United States, and
liver cancer is the second leading cause of cancer-related mortality worldwide. Nonalcoholic …

Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HBV-HCC) pathogenesis is
fueled by persistent HBV infection that stealthily maintains a delicate balance between viral …