Saliva: diagnostics and therapeutic perspectives

N Spielmann, DT Wong - Oral diseases, 2011 - Wiley Online Library
Oral Diseases (2011) 17, 345–354 For the past two decades, salivary diagnostic
approaches have been developed to monitor oral diseases such as periodontal diseases …

Influence of miRNA in insulin signaling pathway and insulin resistance: micro‐molecules with a major role in type‐2 diabetes

C Chakraborty, CGP Doss… - Wiley …, 2014 - Wiley Online Library
The prevalence of type‐2 diabetes (T2D) is increasing significantly throughout the globe
since the last decade. This heterogeneous and multifactorial disease, also known as insulin …

[HTML][HTML] MicroRNA maturation: stepwise processing and subcellular localization

Y Lee, K Jeon, JT Lee, S Kim, VN Kim - The EMBO journal, 2002 - embopress.org
MicroRNAs (miRNAs) constitute a novel, phylogenetically extensive family of small RNAs (∼
22 nucleotides) with potential roles in gene regulation. Apart from the finding that miRNAs …

Fast and effective prediction of microRNA/target duplexes

M Rehmsmeier, P Steffen, M Höchsmann, R Giegerich - Rna, 2004 - rnajournal.cshlp.org
MicroRNAs (miRNAs) are short RNAs that post-transcriptionally regulate the expression of
target genes by binding to the target mRNAs. Although a large number of animal miRNAs …

RNAhybrid: microRNA target prediction easy, fast and flexible

J Krüger, M Rehmsmeier - Nucleic acids research, 2006 - academic.oup.com
In the elucidation of the microRNA regulatory network, knowledge of potential targets is of
highest importance. Among existing target prediction methods, RNAhybrid [M. Rehmsmeier …

Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection

NJ Park, H Zhou, D Elashoff, BS Henson… - Clinical Cancer …, 2009 - AACR
Purpose: We have previously shown that a transcriptome is found in saliva and subpanels of
these mRNAs can be used as oral cancer biomarkers. In this study, we measured the …

Endogenous and silencing-associated small RNAs in plants

C Llave, KD Kasschau, MA Rector… - The Plant Cell, 2002 - academic.oup.com
A large set of endogenous small RNAs of predominantly 21 to 24 nucleotides was identified
in Arabidopsis. These small RNAs resembled micro-RNAs from animals and were similar in …

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

JY Yu, SL DeRuiter, DL Turner - Proceedings of the …, 2002 - National Acad Sciences
Duplexes of 21-nt RNAs, known as short-interfering RNAs (siRNAs), efficiently inhibit gene
expression by RNA interference (RNAi) when introduced into mammalian cells. We show …

Reduced expression of Dicer associated with poor prognosis in lung cancer patients

Y Karube, H Tanaka, H Osada, S Tomida… - Cancer …, 2005 - Wiley Online Library
Emerging evidence suggests that microRNA, which are well‐conserved, abundant and
small regulatory RNA, may be involved in the pathogenesis of human cancers. We recently …

An expanding universe of noncoding RNAs

G Storz - Science, 2002 - science.org
Noncoding RNAs (ncRNAs) have been found to have roles in a great variety of processes,
including transcriptional regulation, chromosome replication, RNA processing and …