Impact of non-invasive biomarkers on hepatology practice: past, present and future

QM Anstee, L Castera, R Loomba - Journal of hepatology, 2022 - Elsevier
Over the last two decades, there have been tremendous advances in the non-invasive
diagnosis and risk stratification of chronic liver diseases (CLDs). Non-invasive approaches …

From NASH to HCC: current concepts and future challenges

QM Anstee, HL Reeves, E Kotsiliti, O Govaere… - Nature reviews …, 2019 - nature.com
Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …

Nonalcoholic fatty liver disease 2020: the state of the disease

TG Cotter, M Rinella - Gastroenterology, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease, with a worldwide
prevalence of 25%. In the United States, NAFLD and its subtype, nonalcoholic …

[HTML][HTML] Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort☆

QM Anstee, R Darlay, S Cockell, M Meroni… - Journal of …, 2020 - Elsevier
Background & Aims Genetic factors associated with non-alcoholic fatty liver disease
(NAFLD) remain incompletely understood. To date, most genome-wide association studies …

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Z Younossi, QM Anstee, M Marietti, T Hardy… - Nature reviews …, 2018 - nature.com
NAFLD is one of the most important causes of liver disease worldwide and will probably
emerge as the leading cause of end-stage liver disease in the coming decades, with the …

MAFLD: A multisystem disease

RM Pipitone, C Ciccioli, G Infantino… - Therapeutic …, 2023 - journals.sagepub.com
Nonalcoholic fatty liver disease (NAFLD), affecting about 25% of general population and
more than 50% of dysmetabolic patients, is an emerging cause of chronic liver disease and …

Mechanisms of hepatic stellate cell activation

T Tsuchida, SL Friedman - Nature reviews Gastroenterology & …, 2017 - nature.com
Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …

[HTML][HTML] Clinical epidemiology and disease burden of nonalcoholic fatty liver disease

BJ Perumpail, MA Khan, ER Yoo… - World journal of …, 2017 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is defined as the presence of hepatic fat
accumulation after the exclusion of other causes of hepatic steatosis, including other causes …

Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases

LA Adams, QM Anstee, H Tilg, G Targher - Gut, 2017 - gut.bmj.com
Key physiological functions of the liver, including glucose and lipid metabolism, become
disturbed in the setting of non-alcoholic fatty liver disease (NAFLD) and may be associated …

Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology

M Eslam, J George - Nature reviews Gastroenterology & hepatology, 2020 - nature.com
Nonalcoholic fatty liver disease (NAFLD) affects around a quarter of the global population,
paralleling worldwide increases in obesity and metabolic syndrome. NAFLD arises in the …