Metagenomics has revolutionized microbiology by paving the way for a cultivation-
independent assessment and exploitation of microbial communities present in complex …

Microorganisms and the viruses that infect them are the most numerous biological entities
on Earth and enclose its greatest biodiversity and genetic reservoir. With strength in their …

Comparative genomics is the cornerstone of identification of gene functions. The immense
number of living organisms precludes experimental identification of functions except in a …

Phages have highly compact genomes with sizes reflecting their capacity to exploit the host
resources. Here, we investigate the reasons for tRNAs being the only translation-associated …

The prevalence of multidrug-resistant Gram-negative bacteria is a public health concern.
Bacteriophages and bacteriophage-derived lytic enzymes have been studied in response to …

Various efforts to integrate biological knowledge into networks of interactions have produced
a lively microbial systems biology. Putting molecular biology and computer sciences in …

Background The genome sequence of the sea-ice bacterium Psychromonas ingrahamii 37,
which grows exponentially at-12C, may reveal features that help to explain how this extreme …

Background Gene expression is regulated through a complex interplay of different
transcription factors (TFs) which can enhance or inhibit gene transcription. ArcA is a global …

The cytoplasm of prokaryotes contains many molecular machines interacting directly with
the chromosome. These vital interactions depend on the chromosome structure, as a …

Background In metagenomic studies, a process called binning is necessary to assign
contigs that belong to multiple species to their respective phylogenetic groups. Most of the …