Understanding the earliest immune responses following HIV infection is critical to inform
future vaccines and therapeutics. Here, we review recent prospective human studies in at …

Pyroptosis is a newly discovered programmed cell death with inflammasome formation.
Pattern recognition receptors that identify repetitive motifs of prospective pathogens such as …

Background Mucosal-associated invariant T (MAIT) cells are systemically depleted in human
immunodeficiency virus type 1 (HIV-1) infected patients and are not replenished even after …

Human immunodeficiency virus type 1 (HIV-1) infection is a chronic disease without a known
cure. The advent of effective antiretroviral therapy (ART) has enabled people with HIV …

Although combined antiretroviral therapy (cART) is effective in inhibiting human
immunodeficiency virus type 1 (HIV-1) replication, it does not eradicate the virus because …

HIV-1 infection results in the activation of inflammasome that may facilitate viral spread and
establishment of viral reservoirs. We evaluated the effects of the caspase-1 inhibitor VX-765 …

Problem Pyroptosis, inflammatory programmed cell death, is initiated through the
inflammasome and relies on the pore‐forming actions of the effector molecule gasdermin D …

The mechanisms underlying depletion of CD4 T cells during acute HIV-1 infection are not
well understood. Here we show that caspase-1-induced pyroptosis, a highly inflammatory …

36.9 million people worldwide are living with HIV-1. The disease remains incurable and HIV-
infected patients have increased risk of atherosclerosis. Inflammation is a key driver of …

Globally, HIV infection causes significant morbidity and mortality, and is a major public
health problem. Despite the fact that widespread use of antiretroviral therapy (ART) has …