Antiseizure drugs (ASDs) prevent the occurrence of seizures; there is no evidence that they
have disease-modifying properties. In the more than 160 years that orally administered …

Rationally designed multi-target drugs (also termed multimodal drugs, network therapeutics,
or designed multiple ligands) have emerged as an attractive drug discovery paradigm in the …

Most general anaesthetics and classical benzodiazepine drugs act through positive
modulation of γ-aminobutyric acid type A (GABAA) receptors to dampen neuronal activity in …

GABA A receptors are pentameric ligand-gated ion channels that mediate most fast
neuronal inhibition in the brain. In addition to their important physiological roles, they are …

Since 1955, several alkyl‐carbamates have been developed for the treatment of anxiety and
epilepsy, including meprobamate, flupirtine, felbamate, retigabine, carisbamate, and …

GABA is a major inhibitory neurotransmitter that regulates the balance between excitatory
and inhibitory circuits in the human nervous system. The GABA receptors are divided into …

This study examines how site-specific binding to three identified neurosteroid-binding sites
in the α1β3 GABAA receptor (GABAAR) contributes to neurosteroid allosteric modulation …

Lipids modulate the function of many ion channels, possibly through direct lipid-protein
interactions. The recent outpouring of ion channel structures by cryo-EM has revealed many …

A 60-year-old woman with a 5-year history of anxiolytic use, a diazepam-equivalent daily
dose of 15 mg, was scheduled for esophageal stent removal. She was given remimazolam …

Abstract Stiripentol (Diacomit®)(STP) is an orally active antiseizure medication (ASM)
indicated as adjunctive therapy, for the treatment of seizures associated with Dravet …