Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

Complement overactivation mediates microglial synapse elimination in neurological
diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), but how …

Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

Our incomplete understanding of the link between Alzheimer's Disease pathology and
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …

Early Alzheimer's disease (AD) is associated with hippocampal hyperactivity and decreased
sleep quality. Here we show that homeostatic mechanisms transiently counteract the …

The physiological balance between excitation and inhibition in the brain is significantly
affected in Alzheimer's disease (AD). Several neuroactive compounds and their signaling …

Synaptic disturbances in excitatory to inhibitory (E/I) balance in forebrain circuits are thought
to contribute to the progression of Alzheimer's disease (AD) and dementia, although direct …

Human Alzheimer's disease (AD) brains and transgenic AD mouse models manifest
hyperexcitability. This aberrant electrical activity is caused by synaptic dysfunction that …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the predominant
impairment of neurons in the hippocampus and the formation of amyloid plaques …