Therapeutic targeting of the angiopoietin–TIE pathway

P Saharinen, L Eklund, K Alitalo - Nature Reviews Drug Discovery, 2017 - nature.com
The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular
permeability and pathological vascular remodelling during inflammation, tumour …

[HTML][HTML] Immune reactions after modern lamellar (DALK, DSAEK, DMEK) versus conventional penetrating corneal transplantation

D Hos, M Matthaei, F Bock, K Maruyama… - Progress in retinal and …, 2019 - Elsevier
In the past decade, novel lamellar keratoplasty techniques such as Deep Anterior Lamellar
Keratoplasty (DALK) for anterior keratoplasty and Descemet stripping automated endothelial …

[HTML][HTML] The hepatic lymphatic vascular system: structure, function, markers, and lymphangiogenesis

M Tanaka, Y Iwakiri - Cellular and molecular gastroenterology and …, 2016 - Elsevier
The lymphatic vascular system has been minimally explored in the liver despite its essential
functions including maintenance of tissue fluid homeostasis. The discovery of specific …

Modeling lymphangiogenesis: Pairing in vitro and in vivo metrics

AC Suarez, JH Hammel, JM Munson - Microcirculation, 2023 - Wiley Online Library
Lymphangiogenesis is the mechanism by which the lymphatic system develops and
expands new vessels facilitating fluid drainage and immune cell trafficking. Models to study …

Lymphangiogenesis guidance mechanisms and therapeutic implications in pathological states of the cornea

M Patnam, SR Dommaraju, F Masood, P Herbst… - Cells, 2023 - mdpi.com
Corneal lymphangiogenesis is one component of the neovascularization observed in
several inflammatory pathologies of the cornea including dry eye disease and corneal graft …

Characterization of ANGPT2 mutations associated with primary lymphedema

VM Leppänen, P Brouillard, EA Korhonen… - Science translational …, 2020 - science.org
Primary lymphedema is caused by developmental and functional defects of the lymphatic
vascular system that result in accumulation of protein-rich fluid in tissues, resulting in edema …

[HTML][HTML] Corneal lymphatics: role in ocular inflammation as inducer and responder of adaptive immunity

SK Chauhan, TH Dohlman, R Dana - Journal of clinical & cellular …, 2014 - ncbi.nlm.nih.gov
The normal cornea is devoid of lymphatic and blood vessels, thus suppressing both the
afferent (lymphatic) and efferent (vascular) arms of the immune response–contributing to its …

Kaposiform lymphangiomatosis treated with multimodal therapy improves coagulopathy and reduces blood angiopoietin‐2 levels

J Crane, J Manfredo, E Boscolo, M Coyan… - Pediatric blood & …, 2020 - Wiley Online Library
Kaposiform lymphangiomatosis (KLA) is a rare, life‐threatening congenital lymphatic
malformation. Diagnosis is often delayed due to complex indistinct symptoms. Blood …

Corneal lymphangiogenesis as a potential target in dry eye disease-a systematic review

M Chennakesavalu, SRR Somala, SR Dommaraju… - Survey of …, 2021 - Elsevier
Dry eye disease (DED) is a common ocular surface condition causing symptoms of
significant discomfort, visual disturbance, and pain. With recent advancements, DED has …

Engineering the lymphatic network: a solution to lymphedema

W Jia, H Hitchcock‐Szilagyi, W He… - Advanced …, 2021 - Wiley Online Library
Secondary lymphedema is a life‐long disorder characterized by chronic tissue swelling and
inflammation that obstruct interstitial fluid circulation and immune cell trafficking …