The biochemistry and effectiveness of antioxidants in food, fruits, and marine algae
It is more effective to maintain good health than to regain it after losing it. This work focuses
on the biochemical defense mechanisms against free radicals and their role in building and …
on the biochemical defense mechanisms against free radicals and their role in building and …
Recent efforts in the discovery of urease inhibitor identifications
WQ Song, ML Liu, SY Li, ZP Xiao - Current Topics in Medicinal …, 2022 - ingentaconnect.com
Urease is an attractive drug target for designing anti-infective agents against pathogens
such as Helicobacter pylori, Proteus mirabilis, and Ureaplasma urealyticum. In the past …
such as Helicobacter pylori, Proteus mirabilis, and Ureaplasma urealyticum. In the past …
Synthetic Transformation of 2-{2-Fluoro[1,1′-biphenyl]-4-yl} Propanoic Acid into Hydrazide–Hydrazone Derivatives: In Vitro Urease Inhibition and In Silico Study
In the present study, 28 acyl hydrazones (4–31) of flurbiprofen were synthesized in good to
excellent yield by reacting different aromatic aldehydes with the commercially available drug …
excellent yield by reacting different aromatic aldehydes with the commercially available drug …
Structural elucidation of rift valley fever virus L protein towards the discovery of its potential inhibitors
Rift valley fever virus (RVFV) is the causative agent of a viral zoonosis that causes a
significant clinical burden in domestic and wild ruminants. Major outbreaks of the virus occur …
significant clinical burden in domestic and wild ruminants. Major outbreaks of the virus occur …
Biallelic Mutations in P4HTM Cause Syndromic Obesity
We previously demonstrated that 50% of children with obesity from consanguineous families
from Pakistan carry pathogenic variants in known monogenic obesity genes. Here, we have …
from Pakistan carry pathogenic variants in known monogenic obesity genes. Here, we have …
[HTML][HTML] The discovery of Zika virus NS2B-NS3 inhibitors with antiviral activity via an integrated virtual screening approach
MU Mirza, I Alanko, M Vanmeert, KM Muzzarelli… - European Journal of …, 2022 - Elsevier
With expanding recent outbreaks and a lack of treatment options, the Zika virus (ZIKV) poses
a severe health concern. The availability of ZIKV NS2B-NS3 co-crystallized structures paved …
a severe health concern. The availability of ZIKV NS2B-NS3 co-crystallized structures paved …
Design, synthesis, characterization and computational studies of mannich bases oxadiazole derivatives as new class of jack bean urease inhibitors
Abstract Mannich bases consisting of 1, 3, 4‐oxadiazole‐2‐thione (3 a–3 l) bearing various
substituents were synthesized and found potent jack bean urease inhibitors. The prepared …
substituents were synthesized and found potent jack bean urease inhibitors. The prepared …
Assessment of phytochemicals, antioxidant, antibacterial activity, and profiling of functional molecules in a freshwater fern, Salvinia cucullata Roxb.
P Santhosh, TG Nithya, SG Lakshmi… - South African Journal of …, 2022 - Elsevier
Salvinia cucullata is a freshwater weed available abundantly in nature and also a
troublesome aquatic weed globally. This study was conducted to know the chances of using …
troublesome aquatic weed globally. This study was conducted to know the chances of using …
Identification of (N-aryl-N-arylsulfonyl) aminoacetohydroxamic acids as novel urease inhibitors and the mechanism exploration
SY Li, Y Zhang, YN Wang, LC Yuan, CC Kong… - Bioorganic …, 2023 - Elsevier
Abstract Thirty-three (N-aryl-N-arylsulfonyl) aminoacetohydroxamic acids were synthesized
in an effort to develop novel urease inhibitors. Among these compounds, 2-(N-(3 …
in an effort to develop novel urease inhibitors. Among these compounds, 2-(N-(3 …
Synthesis and biological evaluation of triazolones/oxadiazolones as novel urease inhibitors
YN Wang, SY Li, LC Yuan, SF Bu, Y Zeng… - Bioorganic & Medicinal …, 2024 - Elsevier
Urease is the main virulence factor of infectious gastritis and gastric ulcers. Urease inhibitors
are regarded as the first choice for the treatment of such diseases. Based on the triazolone …
are regarded as the first choice for the treatment of such diseases. Based on the triazolone …