Increased survival in patients with β thalassemia major (TM) allowed for several
complications of the disease and its treatment to manifest, one of which is bone disease …

Thalassemia bone disease is a common and severe complication of thalassemia—an
inherited blood disorder due to mutations in the α or β hemoglobin gene. In its more severe …

Osteoporosis is a frequent problem in disorders characterized by iron overload, such as the
thalassemias and hereditary hemochromatosis. The exact role of iron in the development of …

Fragility fracture is a worldwide problem and a main cause of disability and impaired quality
of life. It is primarily caused by osteoporosis, characterized by impaired bone quantity and or …

Osteoporosis has until now been considered to be a disease associated with abnormal
calcium metabolism. However, an increasing number of clinical observations strongly …

Osteoporosis is a skeletal disease characterized by decreased bone mass and
microarchitectural changes in bone tissue that increase the susceptibility to fracture …

The pathogenesis of bone resorption in β-thalassemia major is multifactorial and our
understanding of the underlying molecular and cellular mechanisms remains incomplete …

Type 2 diabetes mellitus (T2DM) is associated with an increased risk of osteoporotic
fractures, resulting in disabilities and increased mortality. The pathophysiological …

Secondary osteoporosis is a common clinical problem faced by bone specialists, with a
higher frequency in men than in women. One of several causes of secondary osteoporosis is …

Pulsed electromagnetic fields (PEMFs) have been proven to enhance in vitro and in vivo
osteogenesis with unknown mechanism. Aim of our study was to explore whether …