The molecular interactions underlying regulation of the immune response take place in a
nanoscale gap between T cells and antigen-presenting cells, termed the immunological …

The monoclonal antibody trastuzumab targets the growth factor receptor HER2 and has
profoundly improved the course of disease and survival of women with HER2 …

Simple Summary Natural Killer (NK) cells play a major role in cancer immunotherapy based
on tumor-targeting mAbs. NK cell-mediated tumor cell killing and cytokine secretion are …

Key steps of cancer progression and therapy response depend upon interactions between
cancer cells with the reactive tumour microenvironment. Intravital microscopy enables multi …

Natural killer cells constitute a part of the innate immune system that mediates an effective
immune response towards virus-infected and malignant cells. In recent years, research has …

The activating immunoreceptor NKG2D endows cytotoxic lymphocytes with the capacity to
recognize and eliminate infected or malignant cells. The recognition of such harmful cells is …

The efficacy of most therapeutic monoclonal antibodies (mAbs) targeting tumor antigens
results primarily from their ability to elicit potent cytotoxicity through effector-mediated …

Several studies have shown that in patients with acute leukaemia given allogeneic
haematopoietic stem cell transplantation (allo-HSCT) large part of the therapeutic effect lies …

Natural killer (NK) cells are critical innate immune lymphocytes capable of destroying virally
infected or cancerous cells through targeted cytotoxicity and further assisting in the immune …

Antiangiogenic therapy has shown significant clinical benefits in gastric cancer (GC) and
non-small cell lung cancer (NSCLC). However, their effectiveness is limited by the …