Purpose. To describe the most recent advances in our understanding of the cellular and
molecular mechanisms involved in the immunopathogenesis of corneal …

IL-12, IL-23 and IFN-γ form a loop and have been thought to play a crucial role against
infectious viruses, which are the prototype of “intracellular” pathogens. In the last 10 years …

Naturally occurring CD4+ CD25+ regulatory T cells appear important to prevent activation of
autoreactive T cells. This article demonstrates that the magnitude of a CD8+ T cell–mediated …

We compared the antigen-specific antibody isotypes and lymphokine secretion by CD4+ T
cells in BALB/c mice immunized intradermally with either Escherichia coli beta …

The herpes simplex virus (HSV) infected cell protein (ICP) 47 blocks CD8+ T cell recognition
of infected cells by inhibiting the transporter associated with antigen presentation (TAP). In …

In this communication, we demonstrate that galectin (Gal)-9 acts to constrain CD8+ T cell
immunity to Herpes Simplex Virus (HSV) infection. In support of this, we show that animals …

In vivo evidence suggests that T-cell-derived gamma interferon (IFN-γ) can directly inhibit
the replication of herpes simplex virus type 1 (HSV-1). However, IFN-γ is a weak inhibitor of …

Plasmid DNA encoding proteins represent a convenient novel approach to vaccination. We
have investigated this" genetic immunization" approach as a means to protect against …

This study was initiated to evaluate a role for gamma interferon (IFN-gamma) in herpes
simplex virus type 1 (HSV-1) infection. At the acute stage of infection in mice, HSV-1 …

Intravaginal inoculation of mice with an attenuated strain of herpes simplex virus type 2
(HSV-2) resulted in vigorous HSV-specific immune responses that protected against …