The therapeutic efficacy of B-cell depletion by anti-CD20 treatment in pediatric and, more
recently, in adult idiopathic nephrotic syndrome patients suggests a key role of B cells in the …

Idiopathic nephrotic syndrome is the most common childhood glomerular disease. Most
forms of this syndrome respond to corticosteroids at standard doses and are, therefore …

Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as
well as genes for complex kidney diseases that manifest in combination with environmental …

Pediatric steroid-sensitive nephrotic syndrome (pSSNS) is the most common childhood
glomerular disease. Previous genome-wide association studies (GWAS) identified a risk …

Nephrotic syndrome (NS) is a clinical entity characterized by proteinuria, hypoalbuminemia,
and peripheral edema. NS affects about 2–7 per 100,000 children aged below 18 years old …

Minimal change disease (MCD) is the most common type of idiopathic nephrotic syndrome
in childhood and represents about 15% cases in adults. It is characterized by massive …

Steroid sensitive nephrotic syndrome is a common condition in pediatric nephrology, and
most children have excellent outcomes. Yet, 50% of children will require steroid-sparing …

The field of nephrology has a long-standing interest in deciphering the genetic basis of
nephrotic syndrome (NS), motivated by the mechanistic insights it provides in chronic kidney …

Steroid-sensitive nephrotic syndrome (SSNS) is the most common form of nephrotic
syndrome in childhood and there is growing evidence that genetics play a role in the …

Steroid-resistant nephrotic syndrome (SRNS) is the most severe form of childhood nephrotic
syndrome with an increased risk of progression to chronic kidney disease stage 5. Research …