A bulk of experimental evidence supports the idea that the stroke-damaged adult brain
makes an attempt to repair itself by producing new neurons also in areas where …

JAK-STAT is an efficient and highly regulated system mainly dedicated to the regulation of
gene expression. Primarily identified as functioning in hematopoietic cells, its role has been …

The proliferation and activation of microglial cells is a hallmark of several neurodegenerative
conditions. This mechanism is regulated by the activation of the colony-stimulating factor 1 …

An important component of chronic neurodegenerative diseases is the generation of an
innate inflammatory response within the CNS. Microglial and astroglial cells play a key role …

Systemic or intracerebral delivery of neural stem and progenitor cells (NSPCs) and
activation of endogenous NSPCs hold much promise as potential treatments for diseases in …

Accumulating evidence suggests that there is a rich cross-talk between the neuroimmune
system and neuroplasticity mechanisms under both physiological conditions and …

Innovative pro-regenerative treatment strategies for progressive multiple sclerosis (PMS),
combining neuroprotection and immunomodulation, represent an unmet need. Neural …

Adult neurogenesis in the subventricular zone is a topic of intense research, since it has vast
implications for the fundamental understanding of the neurobiology of the brain and its …

Abstract Interleukin (IL)-15, a member of the immunoregulatory cytokines family, is a
pluripotent molecule with therapeutic potential. It is predominantly expressed by the myeloid …

Cytokines are involved in neural homeostasis and pathological processes associated with
neuroinflammation after spinal cord injury (SCI). The biological effect of cytokines, including …