To understand the placement of a certain protein in a physiological system and the
pathogenesis of related disorders, it is not only of interest to determine its function but also …

Several important physiological processes, from permeability to inflammation to hemostasis,
take place at the vessel wall and are regulated by endothelial cells (ECs). Thus, proteins that …

Hemostasis and pathological thrombus formation are dynamic processes that require
multiple adhesive receptor-ligand interactions, with blood platelets at the heart of such …

Summary von Willebrand factor (VWF) is a protein best known from its critical role in
hemostasis. Indeed, any dysfunction of VWF is associated with a severe bleeding tendency …

Lysosome-related organelles (LROs) comprise a group of cell type-specific subcellular
compartments with unique composition, morphology and structure that share some features …

After a successful invasion, malaria parasite Plasmodium falciparum extensively remodels
the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the …

The blood vessel wall has a number of self‐healing properties, enabling it to minimize blood
loss and prevent or overcome infections in the event of vascular trauma. Endothelial cells …

Summary von W illebrand factor (VWF) plays key roles in both primary and secondary
hemostasis by capturing platelets and chaperoning clotting factor VIII, respectively. It is …

Vascular endothelial cells produce and release compounds regulating vascular tone, blood
vessel growth and differentiation, plasma composition, coagulation and fibrinolysis, and also …

The vascular environment can rapidly alter, and the speed with which responses to both
physiological and pathological changes are required necessitates the existence of a highly …