[HTML][HTML] Biocompute objects—a step towards evaluation and validation of biomedical scientific computations

V Simonyan, J Goecks, R Mazumder - PDA journal of …, 2017 - ncbi.nlm.nih.gov
The unpredictability of actual physical, chemical, and biological experiments due to the
multitude of environmental and procedural factors is well documented. What is …

A cancer cell-line titration series for evaluating somatic classification

RE Denroche, L Mullen, L Timms, T Beck, CK Yung… - BMC Research …, 2015 - Springer
Background Accurate detection of somatic single nucleotide variants and small insertions
and deletions from DNA sequencing experiments of tumour-normal pairs is a challenging …

Reproducibility of snv-calling in multiple sequencing runs from single tumors

DZ Derryberry, MC Cowperthwaite, CO Wilke - PeerJ, 2016 - peerj.com
We examined 55 technical sequencing replicates of Glioblastoma multiforme (GBM) tumors
from The Cancer Genome Atlas (TCGA) to ascertain the degree of repeatability in calling …

Benchmarking of single nucleotide somatic variant calling

DZ Derryberry - 2017 - repositories.lib.utexas.edu
Cancer, which affects hundreds of thousands of people worldwide every year and costs
billions in treatment, is a disease caused by mutations that arise in somatic cell lines and …