The only known function of NAD (P) H oxidases is to produce reactive oxygen species
(ROS). Skeletal muscles express three isoforms of NAD (P) H oxidases (Nox1, Nox2, and …

Abstract Purpose of Review This review presents an overview of the current knowledge of
tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) molecules in inflammation …

Oxidative stress has long been implicated in Parkinson's disease (PD) pathogenesis,
although the sources and regulation of reactive oxygen species (ROS) production are poorly …

Chronic oxidative stress and oxidative damage of the cerebral microvasculature and brain
cells has become one of the most convincing theories in neurodegenerative pathology …

Senescent cells withdraw from the cell cycle and do not proliferate. The prevalence of
senescent compared to normally functioning parenchymal cells increases with age …

Most of diabetic cardiovascular complications are attributed to endothelial dysfunction and
impaired angiogenesis. Endoplasmic Reticulum (ER) and oxidative stresses were shown to …

Heart failure (HF) is a leading cause of death in the United States, with a 5-year mortality
rate of 50% despite modern pharmacological therapies. Plant-based diets are comprised of …

Significance: Numerous studies in animal models and human subjects corroborate that
elevated levels of reactive oxygen species (ROS) play a pivotal role in the progression of …

Endothelial oxidative stress and inflammation attributable to the activation of a Nox2-NADPH
oxidase are key features of many cardiovascular diseases. Here, we report a novel small …

Phagocyte superoxide production by a multicomponent NADPH oxidase is important in host
defense against microbial invasion. However inappropriate NADPH oxidase activation …