An update on the routine application of MALDI-TOF MS in clinical microbiology

M Welker, A Van Belkum, V Girard… - Expert review of …, 2019 - Taylor & Francis
Introduction: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
(MALDI-TOF MS) has entered clinical diagnostics and is today a generally accepted and …

MALDI-TOF mass spectrometry technology as a tool for the rapid diagnosis of antimicrobial resistance in bacteria

EJ Yoon, SH Jeong - Antibiotics, 2021 - mdpi.com
Species identification by using matrix-assisted laser desorption/ionization time-of-flight mass
spectrometry (MALDI-TOF MS) is a routine diagnostic process for infectious diseases in …

Colistin-Resistant Acinetobacter baumannii: Beyond Carbapenem Resistance

ZA Qureshi, LE Hittle, JA O'Hara… - Clinical infectious …, 2015 - academic.oup.com
Background. With an increase in the use of colistin methansulfonate (CMS) to treat
carbapenem-resistant Acinetobacter baumannii infections, colistin resistance is emerging …

A Klebsiella pneumoniae antibiotic resistance mechanism that subdues host defences and promotes virulence

TJ Kidd, G Mills, J Sá‐Pessoa, A Dumigan… - EMBO molecular …, 2017 - embopress.org
Klebsiella pneumoniae is an important cause of multidrug‐resistant infections worldwide.
Recent studies highlight the emergence of multidrug‐resistant K. pneumoniae strains which …

Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection

TWF Lung, D Charytonowicz, KG Beaumont, SS Shah… - Cell metabolism, 2022 - cell.com
K. pneumoniae sequence type 258 (Kp ST258) is a major cause of healthcare-associated
pneumonia. However, it remains unclear how it causes protracted courses of infection in …

Phosphoethanolamine modification of lipid A in colistin-resistant variants of Acinetobacter baumannii mediated by the pmrAB two-component regulatory system

A Beceiro, E Llobet, J Aranda… - Antimicrobial agents …, 2011 - Am Soc Microbiol
Colistin resistance is rare in Acinetobacter baumannii, and little is known about its
mechanism. We investigated the role of PmrCAB in this trait, using (i) resistant and …

Unique structural modifications are present in the lipopolysaccharide from colistin-resistant strains of Acinetobacter baumannii

MR Pelletier, LG Casella, JW Jones… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Acinetobacter baumannii is a nosocomial opportunistic pathogen that can cause severe
infections, including hospital-acquired pneumonia, wound infections, and sepsis. Multidrug …

Resolving colistin resistance and heteroresistance in Enterobacter species

SP Doijad, N Gisch, R Frantz, BV Kumbhar… - Nature …, 2023 - nature.com
Species within the Enterobacter cloacae complex (ECC) include globally important
nosocomial pathogens. A three-year study of ECC in Germany identified Enterobacter …

Structural Modification of Lipopolysaccharide Conferred by mcr-1 in Gram-Negative ESKAPE Pathogens

YY Liu, CE Chandler, LM Leung… - Antimicrobial agents …, 2017 - Am Soc Microbiol
ABSTRACT mcr-1 was initially reported as the first plasmid-mediated colistin resistance
gene in clinical isolates of Escherichia coli and Klebsiella pneumoniae in China and has …

Deciphering tissue-induced Klebsiella pneumoniae lipid A structure

E Llobet, V Martínez-Moliner… - Proceedings of the …, 2015 - National Acad Sciences
The outcome of an infection depends on host recognition of the pathogen, hence leading to
the activation of signaling pathways controlling defense responses. A long-held belief is that …