Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury

S Song, Z Xiao, FJ Dekker, GJ Poelarends… - Cellular and Molecular …, 2022 - Springer
The family of macrophage migration inhibitory factor (MIF) proteins in humans consist of MIF,
its functional homolog D-dopachrome tautomerase (D-DT, also known as MIF-2) and the …

Targeting MIF in cancer: therapeutic strategies, current developments, and future opportunities

C O'Reilly, M Doroudian, L Mawhinney… - Medicinal research …, 2016 - Wiley Online Library
Strong evidence has been presented linking chronic inflammation to the onset and
pathogenesis of cancer. The multifunctional pro‐inflammatory protein macrophage migration …

ZFPM2-AS1, a novel lncRNA, attenuates the p53 pathway and promotes gastric carcinogenesis by stabilizing MIF

F Kong, X Deng, X Kong, Y Du, L Li, H Zhu, Y Wang… - Oncogene, 2018 - nature.com
Long non-coding RNAs (lncRNAs) are implicated to be involved in the pathogenesis of
many cancers. Herein we report on our discovery of a novel lncRNA, ZFPM2 antisense RNA …

Breast cancer and DDT: putative interactions, associated gene alterations, and molecular pathways

VP Jayaseelan, A Ramesh, P Arumugam - Environmental Science and …, 2021 - Springer
The global burden of cancer has recorded an ever-increasing trend in the developing world.
The GLOBOCAN, 2018 report has ranked breast cancer (BC) as the second (11.6%) most …

MIF family proteins in genitourinary cancer: tumorigenic roles and therapeutic potential

JC Penticuff, BL Woolbright, TM Sielecki… - Nature Reviews …, 2019 - nature.com
Genitourinary cancers encompass some of the most common solid tumours and have high
rates of morbidity and mortality. Inflammation is associated with enhanced tumorigenesis …

Macrophage migration inhibitory factor: a multifaceted cytokine implicated in multiple neurological diseases

MF Leyton-Jaimes, J Kahn, A Israelson - Experimental neurology, 2018 - Elsevier
Macrophage migration inhibitory factor (MIF) is a conserved cytokine found as a homotrimer
protein. It is found in a wide spectrum of cell types in the body including neuronal and non …

MIF Maintains the Tumorigenic Capacity of Brain Tumor–Initiating Cells by Directly Inhibiting p53

R Fukaya, S Ohta, T Yaguchi, Y Matsuzaki, E Sugihara… - Cancer Research, 2016 - AACR
Tumor-initiating cells thought to drive brain cancer are embedded in a complex
heterogeneous histology. In this study, we isolated primary cells from 21 human brain tumor …

D-dopachrome tautomerase in cardiovascular and inflammatory diseases-A new kid on the block or just another MIF?

C Zan, B Yang, M Brandhofer… - Faseb …, 2022 - epub.ub.uni-muenchen.de
Macrophage migration inhibitory factor (MIF) as well as its more recently described structural
homolog D-dopachrome tautomerase (D-DT), now also termed MIF-2, are atypical cytokines …

Chronic inflammation, cancer development and immunotherapy

Y Wen, Y Zhu, C Zhang, X Yang, Y Gao, M Li… - Frontiers in …, 2022 - frontiersin.org
Chronic inflammation plays a pivotal role in cancer development. Cancer cells interact with
adjacent cellular components (pro-inflammatory cells, intrinsic immune cells, stromal cells …

The role of MIF in chronic lung diseases: looking beyond inflammation

L Florez-Sampedro, A Soto-Gamez… - … of Physiology-Lung …, 2020 - journals.physiology.org
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been
associated with many diseases. Most studies found in literature describe MIF as a …