Histone deacetylase (HDAC) 6 is the best‐characterized class II b deacetylase that
regulates many important biological processes via the formation of complexes with its …

Microtubules have important functions ranging from maintenance of cell morphology to
subcellular transport, cellular signaling, cell migration, and formation of cell polarity. At the …

Background HDAC6, a structurally and functionally distinct member of the HDAC family, is
an integral part of multiple cellular functions such as cell proliferation, apoptosis …

This Perspective provides an in depth look at the numerous disease states in which histone
deacetylase 6 (HDAC6) has been implicated. The physiological pathways, protein–protein …

Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a
versatile protein that acts as a signaling hub by modulating G protein-coupled receptor …

Increasing evidences point to G protein-coupled receptor kinases (GRKs), a subfamily of
protein kinase A/G/C-like kinases, as relevant players in cancer progression, in a cell-type …

The special class IIb histone deacetylase, HDAC6, plays a prominent role in many cellular
processes related to cancer, including oncogenesis, the cell stress response, motility, and …

G protein-coupled receptor kinases (GRKs) are emerging as important integrative nodes in
cell migration processes. Recent evidence links GRKs (particularly the GRK2 isoform) to the …

Malignant features—such as sustained proliferation, refractoriness to growth suppressors,
resistance to cell death or aberrant motility, and metastasis—can be triggered by a variety of …

Oxidative stress is defined as an injury resulting from a disturbance in the dynamic
equilibrium of the redox environment due to the overproduction of active/radical oxygen …