Role of redox signaling in neuroinflammation and neurodegenerative diseases
HL Hsieh, CM Yang - BioMed research international, 2013 - Wiley Online Library
Reactive oxygen species (ROS), a redox signal, are produced by various enzymatic
reactions and chemical processes, which are essential for many physiological functions and …
reactions and chemical processes, which are essential for many physiological functions and …
LPS preconditioning attenuates apoptosis mechanism by inhibiting NF-κB and caspase-3 activity: TLR4 pre-activation in the signaling pathway of LPS-induced …
Neuroinflammation, an inflammatory response within the nervous system, has been shown
to be implicated in the progression of various neurodegenerative diseases. Recent in vivo …
to be implicated in the progression of various neurodegenerative diseases. Recent in vivo …
Propofol attenuates TNF-α-induced MMP-9 expression in human cerebral microvascular endothelial cells by inhibiting Ca2+/CAMK II/ERK/NF-κB signaling pathway
X Ding, X Sun, X Shen, Y Lu, J Wang, Z Sun… - Acta Pharmacologica …, 2019 - nature.com
Abstract Metalloproteinase 9 (MMP-9) is able to degrade collagen IV, an important
component of blood–brain barrier (BBB). Expression of MMPs, especially MMP-9, correlates …
component of blood–brain barrier (BBB). Expression of MMPs, especially MMP-9, correlates …
Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms
A Nokkari, H Abou-El-Hassan, Y Mechref… - Progress in …, 2018 - Elsevier
Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …
mortality worldwide. Despite a tremendous increase in our understanding of the …
Bradykinin B1 Receptor Affects Tumor-Associated Macrophage Activity and Glioblastoma Progression
CK Shen, BR Huang, V Charoensaensuk, LY Yang… - Antioxidants, 2023 - mdpi.com
Bradykinin is a small active peptide and is considered an inflammatory mediator in several
pathological conditions. Bradykinin exerts its effects by coupling to its receptors, including …
pathological conditions. Bradykinin exerts its effects by coupling to its receptors, including …
The TNF-α/Nf-κB Signaling Pathway has a Key Role in Methamphetamine–Induced Blood–Brain Barrier Dysfunction
V Coelho-Santos, RA Leitão… - Journal of Cerebral …, 2015 - journals.sagepub.com
Methamphetamine (METH) is a psychostimulant that causes neurologic and psychiatric
abnormalities. Recent studies have suggested that its neurotoxicity may also result from its …
abnormalities. Recent studies have suggested that its neurotoxicity may also result from its …
Rottlerin, a natural polyphenol compound, inhibits upregulation of matrix metalloproteinase-9 and brain astrocytic migration by reducing PKC-δ-dependent ROS signal
TH Lee, JL Chen, PS Liu, MM Tsai, SJ Wang… - Journal of …, 2020 - Springer
Background Upregulation of matrix metalloproteinase-9 (MMP-9) has been indicated as one
of the inflammatory biomarkers. In the central nervous system (CNS), the MMP-9 is induced …
of the inflammatory biomarkers. In the central nervous system (CNS), the MMP-9 is induced …
A novel histone deacetylase 1 and 2 isoform-specific inhibitor alleviates experimental Parkinson's disease
CJ Choong, T Sasaki, H Hayakawa, T Yasuda… - Neurobiology of …, 2016 - Elsevier
With increased histone deacetylase (HDAC) activity and histone hypoacetylation being
implicated in neurodegeneration, HDAC inhibitors have been reported to have considerable …
implicated in neurodegeneration, HDAC inhibitors have been reported to have considerable …
Oxidative modification and its implications for the neurodegeneration of Parkinson's disease
J Zhao, S Yu, Y Zheng, H Yang, J Zhang - Molecular neurobiology, 2017 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disease. The
major characteristics of PD include the loss of dopaminergic neurons in the substantia nigra …
major characteristics of PD include the loss of dopaminergic neurons in the substantia nigra …
High-glucose-derived oxidative stress-dependent heme oxygenase-1 expression from astrocytes contributes to the neuronal apoptosis
CM Yang, CC Lin, HL Hsieh - Molecular neurobiology, 2017 - Springer
An elevated level of glucose has been found in the blood of hyperglycemia and diabetes
patients associated with several central nervous system (CNS) complications. These …
patients associated with several central nervous system (CNS) complications. These …