Introduction When the COVID-19 pandemic struck no specific therapies were available and
many turned to COVID-19 convalescent plasma (CCP), a form of antibody therapy. The …

Three years after the start of the pandemic, approaches to the prevention and treatment of
acute Covid-19 have been established. However, post-acute sequelae of SARS-CoV-2 …

Importance Among critically ill adults, randomized trials have not found oxygenation targets
to affect outcomes overall. Whether the effects of oxygenation targets differ based on an …

Sepsis is accompanied by thrombocytopenia and the severity of the thrombocytopenia is
associated with mortality. This thrombocytopenia is characteristic of disseminated …

Clinicians know that individual patients may respond differently to a given treatment and that
the overall treatment effect reported in a randomized trial of the treatment may not be directly …

Based on emerging evidence from the COVID-19 pandemic, the International Society on
Thrombosis and Haemostasis (ISTH) guidelines for antithrombotic treatment in COVID-19 …

Recent clinical and research efforts in cardiogenic shock (CS) have largely focussed on the
restoration of the low cardiac output state that is the conditio sine qua non of the clinical …

Recent studies have revealed that tumor-associated macrophages are the most abundant
stromal cells in the tumor microenvironment and play an important role in tumor initiation …

Importance Subgroup analyses are often performed in oncology to investigate differential
treatment effects and may even constitute the basis for regulatory approvals. Current …

At present, the management of patients with acute respiratory distress syndrome (ARDS)
largely focuses on ventilator settings to limit intrathoracic pressures by using low tidal …