Genetic factors strongly affect susceptibility to common diseases and also influence disease-
related quantitative traits. Identifying the relevant genes has been difficult, in part because …

There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans
and other species. Characterizing LD is of central importance for gene-mapping studies and …

Common genetic polymorphisms may explain a portion of the heritable risk for common
diseases. Within candidate genes, the number of common polymorphisms is finite, but direct …

Delineating the tremendous growth in this area, the Handbook of Approximation Algorithms
and Metaheuristics covers fundamental, theoretical topics as well as advanced, practical …

Modern scientific studies often require the identification of a subset of explanatory variables.
Several statistical methods have been developed to automate this task, and the framework …

Compared to the conventional linkage mapping, linkage disequilibrium (LD)‐mapping,
using the nonrandom associations of loci in haplotypes, is a powerful high‐resolution …

Human geneticists working on systems for which it is possible to make a strong case for a
set of candidate genes face the problem of whether it is necessary to consider the variation …

The mapping of SNPs in human genomes has generated a lot of interest from both the
biomedical research community and industry. In conjunction with SNP mapping, researchers …

We consider the variable selection problem, which seeks to identify important variables
influencing a response Y out of many candidate features X ₁,..., Xp. We wish to do so while …

In the 'indirect'method of detecting genetic associations between a trait and a DNA variant,
we type several markers in a gene or chromosome region of linkage disequilibrium. If there …