Congenital heart defects constitute the most common human birth defect, however
understanding of how these disorders originate is limited by our ability to model the human …

Cardiac organoids are in vitro self-organizing and three-dimensional structures composed of
multiple cardiac cells (ie, cardiomyocytes, endothelial cells, cardiac fibroblasts, etc.) with or …

The number one cause of human fetal death are defects in heart development. Because the
human embryonic heart is inaccessible and the impacts of mutations, drugs, and …

Heart development is a continuous process involving significant remodeling during
embryogenesis and neonatal stages. To date, several groups have used single-cell …

Recent development of human three-dimensional organoid cultures has opened new doors
and opportunities ranging from modelling human development in vitro to personalised …

The survival of malignant tumors is highly dependent on their intrinsic self-defense pathways
such as heat shock protein (HSP) during cancer therapy. However, precisely dismantling …

The epicardium, the outer epithelial layer that covers the myocardium, derives from a
transient organ known as pro-epicardium, crucial during heart organogenesis. The pro …

Organoid Intelligence ushers in a new era by seamlessly integrating cutting-edge organoid
technology with the power of artificial intelligence. Organoids, three-dimensional miniature …

Introduction Recent advances in human cardiac 3D approaches have yielded progressively
more complex and physiologically relevant culture systems. However, their application in the …

Human neural organoids offer an exciting opportunity for studying inaccessible human-
specific brain development; however, it remains unclear how precisely organoids …