Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …

Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …

Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

All life forms defend their genome against DNA invasion. Eukaryotic cells recognize
incoming DNA and limit its transcription through repressive chromatin modifications. The …

Features of the cancer epigenome distinguish cancers from their respective cell of origin and
establish therapeutic vulnerabilities that can be exploited through pharmacologic inhibition …

Transposable element (TE)-derived sequences are ubiquitous in most eukaryotic genomes
known to date. Because their expression and mobility can lead to genomic instability …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that
results in significant neurodegeneration in the majority of those affected and is a common …

Almost half of the human genome is made up of transposable elements (TEs), and about 8%
consists of endogenous retroviruses (ERVs). ERVs are remnants of ancient exogenous …

The human silencing hub (HUSH) preserves genome integrity through the epigenetic
repression of invasive genetic elements. However, despite our understanding of HUSH as …

Abstract The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression
of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary …