Evolutionarily conserved Notch plays a critical role in embryonic development and cellular
self-renewal. It has both tumour suppressor and oncogenic activity, the latter of which is …

Members of the Notch family of transmembrane receptors play an important role in cell fate
determination. Over the past decade, a role for Notch in the pathogenesis of hematologic …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy and
new therapeutics are much needed. Profiling patient leukemia drug sensitivities ex vivo, we …

Notch signals are necessary for the functional outcomes of T cell receptor β-selection,
including differentiation, proliferation and rescue from apoptosis. The mechanism underlying …

T-cell acute lymphoblastic leukaemia (T-ALL) is induced by the transformation of T-cell
progenitors and mainly occurs in children and adolescents. Although treatment outcome in …

Notch proteins regulate a broad spectrum of cell fate decisions and differentiation processes
during fetal and postnatal development. Mammals have four Notch receptors that bind five …

Notch signaling plays a key role in the normal development of many tissues and cell types,
through diverse effects on differentiation, survival, and/or proliferation that are highly …

Abstract The chromosomal translocation t (7; 9) in human T-cell acute lymphoblastic
leukaemia (T-ALL) results in deregulated expression of a truncated, activated form of Notch …

Canonical Notch signaling is initiated by γ-secretase-mediated cleavage of the Notch
receptor, leading to the release of the active intra-cellular domain of Notch that migrates to …

Using a combination of molecular cytogenetic and large-scale expression analysis in human
T-cell acute lymphoblastic leukemias (T-ALLs), we identified and characterized a new …