Covid-19 vaccines—immunity, variants, boosters

DH Barouch - New England Journal of Medicine, 2022 - Mass Medical Soc
Covid-19 Vaccines — Immunity, Variants, Boosters | New England Journal of Medicine Skip to
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Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection

A Zhang, HD Stacey, MR D'Agostino, Y Tugg… - Nature Reviews …, 2023 - nature.com
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …

Low neutralization of SARS-CoV-2 Omicron BA. 2.75. 2, BQ. 1.1 and XBB. 1 by parental mRNA vaccine or a BA. 5 bivalent booster

C Kurhade, J Zou, H Xia, M Liu, HC Chang, P Ren… - Nature medicine, 2023 - nature.com
The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Omicron sublineages, including the BA. 2-derived BA. 2.75. 2 and the BA. 5-derived BQ. 1.1 …

Neutralization, effector function and immune imprinting of Omicron variants

A Addetia, L Piccoli, JB Case, YJ Park, M Beltramello… - Nature, 2023 - nature.com
Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots
in the receptor-binding domain (RBD) of the spike protein. The effects of these mutations on …

Defining the risk of SARS-CoV-2 variants on immune protection

MM DeGrace, E Ghedin, MB Frieman, F Krammer… - Nature, 2022 - nature.com
The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or …

SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines

JE Bowen, YJ Park, C Stewart, JT Brown… - Science …, 2022 - science.org
Numerous safe and effective coronavirus disease 2019 vaccines have been developed
worldwide that use various delivery technologies and engineering strategies. We show here …

[HTML][HTML] IgG4 antibodies induced by repeated vaccination may generate immune tolerance to the SARS-CoV-2 spike protein

VN Uversky, EM Redwan, W Makis, A Rubio-Casillas - Vaccines, 2023 - mdpi.com
Less than a year after the global emergence of the coronavirus SARS-CoV-2, a novel
vaccine platform based on mRNA technology was introduced to the market. Globally, around …

Less neutralization evasion of SARS-CoV-2 BA. 2.86 than XBB sublineages and CH. 1.1

Y Hu, J Zou, C Kurhade, X Deng… - Emerging microbes & …, 2023 - Taylor & Francis
ABSTRACT The highly mutated BA. 2.86, with over 30 spike protein mutations in
comparison to Omicron BA. 2 and XBB. 1.5 variants, has raised concerns about its potential …

Effectiveness of inactivated and Ad5-nCoV COVID-19 vaccines against SARS-CoV-2 Omicron BA. 2 variant infection, severe illness, and death

Z Huang, S Xu, J Liu, L Wu, J Qiu, N Wang, J Ren, Z Li… - BMC medicine, 2022 - Springer
Background Limited data are available on the effectiveness of inactivated and Ad5-nCoV
COVID-19 vaccines in real-world use—especially against Omicron variants in SARS-CoV-2 …

Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant

F Zuo, H Abolhassani, L Du, A Piralla… - Nature …, 2022 - nature.com
The recent emergence of the Omicron variant has raised concerns on vaccine efficacy and
the urgent need to study more efficient vaccination strategies. Here we observed that an …