Gestational diabetes mellitus

HD McIntyre, P Catalano, C Zhang, G Desoye… - Nature reviews Disease …, 2019 - nature.com
Hyperglycaemia that develops during pregnancy and resolves after birth has been
recognized for over 50 years, but uniform worldwide consensus is lacking about threshold …

Pathophysiology from preconception, during pregnancy, and beyond

MF Hivert, H Backman, K Benhalima, P Catalano… - The Lancet, 2024 - thelancet.com
Gestational diabetes is the most common medical complication in pregnancy. Historically,
gestational diabetes was considered a pregnancy complication involving treatment of rising …

Physiology and pathophysiology of steroid biosynthesis, transport and metabolism in the human placenta

W Chatuphonprasert, K Jarukamjorn… - Frontiers in …, 2018 - frontiersin.org
The steroid hormones progestagens, estrogens, androgens, and glucocorticoids as well as
their precursor cholesterol are required for successful establishment and maintenance of …

[HTML][HTML] Adipose tissue development and lipid metabolism in the human fetus: The 2020 perspective focusing on maternal diabetes and obesity

G Desoye, E Herrera - Progress in lipid research, 2021 - Elsevier
During development, the human fetus accrues the highest proportion of fat of all mammals.
Precursors of fat lobules can be found at week 14 of pregnancy. Thereafter, they expand …

The human placenta in diabetes and obesity: friend or foe? The 2017 Norbert Freinkel Award Lecture

G Desoye - Diabetes care, 2018 - Am Diabetes Assoc
The placenta plays a key role in sustaining fetal growth and development. Due to its position
between mother and fetus, it is exposed to changes in the intrauterine environment in both …

Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia

B Fuenzalida, C Cantin, S Kallol, L Carvajal… - Scientific reports, 2020 - nature.com
Maternal physiological (MPH) or supraphysiological hypercholesterolaemia (MSPH) occurs
during pregnancy. Cholesterol trafficking from maternal to foetal circulation requires the …

Pregnancies in diabetes and obesity: the capacity-load model of placental adaptation

G Desoye, JCK Wells - Diabetes, 2021 - Am Diabetes Assoc
Excess nutritional supply to the growing fetus, resulting from maternal diabetes and obesity,
is associated with increased risks of fetal maldevelopment and adverse metabolic conditions …

[HTML][HTML] p66Shc-mediated oxidative stress is involved in gestational diabetes mellitus

TT Huang, WJ Sun, HY Liu, HL Ma… - World Journal of …, 2021 - ncbi.nlm.nih.gov
BACKGROUND Gestational diabetes mellitus (GDM) is associated with a heightened level
of oxidative stress, which is characterized by the overproduction of reactive oxygen species …

[HTML][HTML] Mitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus

L Sobrevia, P Valero, A Grismaldo… - … Et Biophysica Acta (BBA …, 2020 - Elsevier
Gestational diabetes mellitus (GDM) is a disease of pregnancy that is associated with d-
glucose intolerance and foeto-placental vascular dysfunction. GMD causes mitochondrial …

Platelets and endothelial dysfunction in gestational diabetes mellitus

P Valero, M Cornejo, G Fuentes, S Wehinger… - Acta …, 2023 - Wiley Online Library
The prevalence of gestational diabetes mellitus (GDM) has increased in recent years, along
with the higher prevalence of obesity in women of reproductive age. GDM is a pathology …