The Human Eye Proteome Project: perspectives on an emerging proteome

RD Semba, JJ Enghild, V Venkatraman… - …, 2013 - Wiley Online Library
There are an estimated 285 million people with visual impairment worldwide, of whom 39
million are blind. The pathogenesis of many eye diseases remains poorly understood. The …

Comparative performance of the BGISEQ-500 vs Illumina HiSeq2500 sequencing platforms for palaeogenomic sequencing

SST Mak, S Gopalakrishnan, C Carøe, C Geng… - …, 2017 - academic.oup.com
Ancient DNA research has been revolutionized following development of next-generation
sequencing platforms. Although a number of such platforms have been applied to ancient …

[HTML][HTML] Spider genomes provide insight into composition and evolution of venom and silk

KW Sanggaard, JS Bechsgaard, X Fang, J Duan… - Nature …, 2014 - nature.com
Spiders are ecologically important predators with complex venom and extraordinarily tough
silk that enables capture of large prey. Here we present the assembled genome of the social …

A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α

S Chen, NE Hoffman, S Shanmughapriya, L Bao… - Journal of Biological …, 2014 - ASBMB
The calcium-permeable ion channel TRPM2 is highly expressed in a number of cancers. In
neuroblastoma, full-length TRPM2 (TRPM2-L) protected cells from moderate oxidative stress …

TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria

BA Miller, NE Hoffman, S Merali, XQ Zhang… - Journal of Biological …, 2014 - ASBMB
Cardiac TRPM2 channels were activated by intracellular adenosine diphosphate-ribose and
blocked by flufenamic acid. In adult cardiac myocytes the ratio of G Ca to G Na of TRPM2 …

HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis

CA Barrero, PK Datta, S Sen, S Deshmane, S Amini… - PloS one, 2013 - journals.plos.org
Human immunodeficiency virus type 1 encoded viral protein Vpr is essential for infection of
macrophages by HIV-1. Furthermore, these macrophages are resistant to cell death and are …

The protein composition of the digestive fluid from the venus flytrap sheds light on prey digestion mechanisms

WX Schulze, KW Sanggaard, I Kreuzer… - Molecular & Cellular …, 2012 - ASBMB
The Venus flytrap (Dionaea muscipula) is one of the most well-known carnivorous plants
because of its unique ability to capture small animals, usually insects or spiders, through a …

Coagulation factor XIIIa substrates in human plasma: identification and incorporation into the clot

CL Nikolajsen, TF Dyrlund, ET Poulsen… - Journal of Biological …, 2014 - ASBMB
Coagulation factor XIII (FXIII) is a transglutaminase with a well defined role in the final stages
of blood coagulation. Active FXIII (FXIIIa) catalyzes the formation of ϵ-(γ-glutamyl) lysine …

Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain

M Richner, LT Pallesen, M Ulrichsen, ET Poulsen… - Science …, 2019 - science.org
Neuropathic pain is a major incurable clinical problem resulting from peripheral nerve
trauma or disease. A central mechanism is the reduced expression of the potassium chloride …

Unconditioned commercial embryo culture media contain a large variety of non-declared proteins: a comprehensive proteomics analysis

TF Dyrlund, K Kirkegaard, ET Poulsen… - Human …, 2014 - academic.oup.com
STUDY QUESTION Which non-declared proteins (proteins not listed on the composition list
of the product data sheet) are present in unconditioned commercial embryo culture media …