The miR-200 family of microRNAs: fine tuners of epithelial-mesenchymal transition and circulating cancer biomarkers

I Cavallari, F Ciccarese, E Sharova, L Urso… - Cancers, 2021 - mdpi.com
Simple Summary MicroRNAs (miRNAs) are small RNA molecules that regulate gene
expression by blocking translation or inducing degradation of specific gene transcripts. The …

Targeting cell signaling in allergic asthma

SS Athari - Signal transduction and targeted therapy, 2019 - nature.com
Asthma is chronic inflammation of the airways characterized by airway hyper-
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …

Decreased miR-214–3p activates NF-κB pathway and aggravates osteoarthritis progression

Y Cao, X Nie, Z Zhou, G Ruan, W Han, Z Zhu, C Ding - …, 2021 - thelancet.com
Background Osteoarthritis (OA), a disease with whole-joint damage and dysfunction, is the
leading cause of disability worldwide. The progressive loss of hyaline cartilage extracellular …

MicroRNAs in breast cancer: Roles, functions, and mechanism of actions

M Abolghasemi, SS Tehrani, T Yousefi… - Journal of cellular …, 2020 - Wiley Online Library
Breast cancer is one of the most lethal malignancies in women in the world. Various factors
are involved in the development and promotion of the malignancy; most of them involve …

[HTML][HTML] The microRNAs miR-200b-3p and miR-429-5p target the LIMK1/CFL1 pathway to inhibit growth and motility of breast cancer cells

D Li, H Wang, H Song, H Xu, B Zhao, C Wu, J Hu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC) has the worst prognosis of all subtypes of breast
cancer (BC), with limited options for conventional therapy and no targeted therapies …

The role of miR-200 family in the regulation of hallmarks of cancer

K Klicka, TM Grzywa, A Mielniczuk, A Klinke… - Frontiers in …, 2022 - frontiersin.org
MiRNAs are short non-coding RNAs that regulate gene expression post-transcriptionally
contributing to the development of different diseases including cancer. The miR-200 family …

Recent advances in endotoxin tolerance

D Liu, S Cao, Y Zhou, Y Xiong - Journal of cellular biochemistry, 2019 - Wiley Online Library
Endotoxin tolerance is defined as a reduced capacity of a cell to respond endotoxin
(lipopolysaccharide, LPS) challenge after an initial encounter with endotoxin in advance …

Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine

S Kopp, L Slumstrup, TJ Corydon, J Sahana… - Scientific reports, 2016 - nature.com
Many cell types form three-dimensional aggregates (MCS; multicellular spheroids), when
they are cultured under microgravity. MCS often resemble the organ, from which the cells …

MicroRNA-enriched small extracellular vesicles possess odonto-immunomodulatory properties for modulating the immune response of macrophages and promoting …

J Zheng, Y Kong, X Hu, Z Li, Y Li, Y Zhong… - Stem cell research & …, 2020 - Springer
Background To investigate the odonto-immunomodulatory properties of dental pulp stem
cell-derived small extracellular vesicles (DPSCs-sEV), which promote odontogenesis by …

Advances in IKBKE as a potential target for cancer therapy

M Yin, X Wang, J Lu - Cancer medicine, 2020 - Wiley Online Library
IKBKE (inhibitor of nuclear factor kappa‐B kinase subunit epsilon), a member of the
nonclassical IKK family, plays an important role in the regulation of inflammatory reactions …