The important protozoan parasites including Plasmodium, Leishmania, Toxoplasma,
Trypanosoma and Giardia have been proved as the main reason initiating and developing …

Malaria has been a major parasitic disease in tropical and subtropical regions and is
estimated to kill between one and two million people (mainly children) every year. Novel anti …

Phenols are widespread in nature, being the major components of several plants and
essential oils. Natural phenols' anti-microbial, anti-bacterial, anti-oxidant, pharmacological …

Carvacrol, called CA, is a dynamic phytoconstituent characterized by a phenol ring
abundantly sourced from various natural reservoirs. This versatile scaffold serves as a …

The resistance of conventional antimalarial drugs against the malarial parasite continues to
pose a challenge to control the disease. The indiscriminate exploitation of the available …

In this work, substituted 1, 2, 4-oxadiazoles (OX1–OX27) were screened against five
bacterial strains, identified to be OX7 and OX11 as growth inhibitors with minimum inhibitory …

The persistence of drug resistance poses a significant obstacle to the advancement of
efficacious malaria treatments. The remarkable efficacy displayed by 1, 2, 3-triazole-based …

A large family of enzymes with the function of hydrolyzing peptide bonds, called peptidases
or cysteine proteases (CPs), are divided into three categories according to the peptide chain …

We employed a comprehensive approach of target-based virtual high-throughput screening
to find potential hits from the ZINC database of natural compounds against cysteine …

This study performed a comparative investigation to explore the interaction mechanisms
between two potential antimalarial compounds, JMI 346 and JMI 105, and human serum …